Leeno: Type 1 diabetes management training environment using smart algorithms.

A growing number of Type-1 Diabetes (T1D) patients globally use insulin pump technologies to monitor and manage their glucose levels. Although recent advances in closed-loop systems promise automated pump control in the near future, most patients worldwide still use open-loop continuous subcutaneous insulin infusion (CSII) devices which require close monitoring and continuous regulation. Apart from specialized diabetes units, hospital physicians and nurses generally lack necessary training to support the growing number of patients on insulin pumps.

Unraveling the stability landscape of mutations in the SARS-CoV-2 receptor-binding domain.

The interaction between the receptor-binding domain (RBD) of the SARS-CoV-2 spike glycoprotein and the ACE2 enzyme is believed to be the entry point of the virus into various cells in the body, including the lungs, heart, liver, and kidneys. The current focus of several therapeutic design efforts explores attempts at affecting the binding potential between the two proteins to limit the activity of the virus and disease progression. In this work, we analyze the stability of the spike protein under all possible single-point mutations in the RBD and computationally explore mutations that can affect the binding with the ACE2 enzyme.

Development platform for artificial pancreas algorithms.

Background And Aims: Assessing algorithms of artificial pancreas systems is critical in developing automated and fault-tolerant solutions that work outside clinical settings. The development and evaluation of algorithms can be facilitated with a platform that conducts virtual clinical trials. We present in this paper a clinically validated cloud-based distributed platform that supports the development and comprehensive testing of single and dual-hormone algorithms for type 1 diabetes mellitus (T1DM).

Periostitis Ossificans: Report of Two Cases Resolved with Endodontic Treatment.

Periostitis ossificans is a chronic disease characterized by an ossifying periostitis, occurring in children and young adults, commonly as a reaction to a mild infection or irritation. It is also characterized by the presence of lamellae of newly formed periosteal bone outside the cortex, giving the characteristic radiographic appearance of "onion skin." .

Model-based reconstruction of the Ulysse-Virginia oil spill, October-November 2018.

In response to the oil spill caused by the collision between the Ro-Ro ship Ulysse and CSL Virginia on 7 October 2018, the Lagrangian oil spill model MEDSLIK-II was utilized to predict spill transport and fate. Oil drift was forced by the high-resolution sea circulation provided by CMEMS and the ECMWF wind. Successive model runs were restarted 5 times with the distinct overflight- and satellite-derived observations provided by REMPEC and the Copernicus Sentinel-1 mission.