Publications by authors named "M Smahel"
Article Synopsis
- Cancer immunotherapy is facing challenges due to tumors adapting and escaping the immune response, partly due to the genetic instability of tumor cells.
- A study using a mouse model of HPV-induced tumors explored the variations in immune cell presence, gene expression, and mutations across different tumor areas post-immunotherapy.
- Results showed an increase in mutations with significant effects on genes related to immune processes and tumor interactions, highlighting intratumoral immune heterogeneity as a factor contributing to the failure of immunotherapy.
Three series of spiropyran photoswitches with an auxiliary chiral centre at position 3' of the indoline unit were synthesized. Using one example, a novel methodology for synthesis of an optically active spiropyran photoswitch with a defined chirality at position 3' is demonstrated. Furthermore, a new acid-mediated strategy for spiropyran purification affording moderate to excellent yields (up to 96%) is reported herein.
View Article and Find Full Text PDFBackground: A proportion of head and neck carcinomas (HNSCCs) are induced by high-risk human papillomaviruses (HPVs) and are associated with better patient outcomes compared to patients with HNSCCs related to tobacco and alcohol abuse. In the microenvironment of solid tumors, including HNSCCs, oxygen levels are often reduced, and a hypoxic state is induced. This can lead to a poor treatment response and a worse patient prognosis.
View Article and Find Full Text PDF: Cancer development involves alterations in key cellular pathways, with aspartate β-hydroxylase (ASPH) emerging as an important player in tumorigenesis. ASPH is upregulated in various cancer types, where it promotes cancer progression mainly by regulating the Notch1 and SRC pathways. : This study explored the responses of various human cervical, pharyngeal, and breast tumor cell lines to second- and third-generation ASPH inhibitors (MO-I-1151 and MO-I-1182) using proliferation, migration, and invasion assays; western blotting; and cell cycle analysis.
View Article and Find Full Text PDFBackground: SARS-CoV-2, which causes COVID-19, has killed more than 7 million people worldwide. Understanding the development of postinfectious and postvaccination immune responses is necessary for effective treatment and the introduction of appropriate antipandemic measures.
Objectives: We analysed humoral and cell-mediated anti-SARS-CoV-2 immune responses to spike (S), nucleocapsid (N), membrane (M), and open reading frame (O) proteins in individuals collected up to 1.