Publications by authors named "M Sivina"
Deuterated ("heavy") water labeling in patients with chronic lymphocytic leukemia (CLL) demonstrates that IGHV unmutated and ZAP-70+ patients have higher blood and tissue CLL death rates on ibrutinib therapy, resulting in lower measurable residual disease levels with long-term ibrutinib treatment. This trial was registered at www.clinicaltrials.
View Article and Find Full Text PDFThe T-box transcription factor T-bet is known as a master regulator of the T-cell response but its role in malignant B cells has not been sufficiently explored. Here, we conducted single-cell resolved multi-omics analyses of malignant B cells from patients with chronic lymphocytic leukemia (CLL) and studied a CLL mouse model with a genetic knockout of Tbx21. We found that T-bet acts as a tumor suppressor in malignant B cells by decreasing their proliferation rate.
View Article and Find Full Text PDFArticle Synopsis
- * A comprehensive analysis of data from 1,148 patients led to the identification of 202 genetic drivers of CLL, including 109 that were previously unrecognized, and refined the understanding of IGHV subtypes.
- * This research not only clarifies the genomic landscape of CLL but also uncovers new gene expression subtypes that serve as independent prognostic factors, enhancing the prediction of clinical outcomes.
Article Synopsis
- Chronic lymphocytic leukemia (CLL) involves complex interactions between CLL cells and various T-cell subsets, particularly in the lymph node microenvironment where these interactions are important for disease development.
- In co-cultures of CLL nurselike cells (NLC) from 28 patients, researchers observed significant expansion of T-follicular helper (Tfh) cells characterized by specific protein expressions, alongside an increase in regulatory T cells (Treg) that help maintain immune tolerance.
- Using advanced microscopy, the study revealed that Tfh cells closely interact with proliferating CLL cells in lymph nodes, highlighting potential targets for new therapies aimed at disrupting this harmful interaction.