Publications by authors named "M Siu"
T cells develop from hematopoietic progenitors in the thymus and protect against pathogens and cancer. However, the emergence of human T cell-competent blood progenitors and their subsequent specification to the T lineage have been challenging to capture in real time. Here, we leveraged a pluripotent stem cell differentiation system to understand the transcriptional dynamics and cell fate restriction events that underlie this critical developmental process.
View Article and Find Full Text PDFPercutaneous Cholecystostomy for Acute Cholecystitis During Spaceflight.
Aerosp Med Hum Perform
October 2024
Introduction: Acute calculous cholecystitis is a common surgical emergency and cholecystectomy is the gold-standard treatment. However, alternative drainage modalities such as percutaneous cholecystostomy tube (PCT) placement have been proposed for poor surgical candidates or in remote environments, such as space. We reviewed the literature to assess the theoretical utility of PCT to treat acute cholecystitis during long-duration spaceflight or on the Moon or Mars.
View Article and Find Full Text PDFArticle Synopsis
- HPK1 is a negative regulator of T-cell receptor signaling, and its inhibition can enhance immune responses and work well with immune checkpoint inhibitors in cancer models.
- Researchers have discovered a new series of isoquinoline compounds that effectively inhibit HPK1 and promote T-cell activity through fragment-based screening.
- The best candidate from these efforts showed strong inhibition of HPK1, excellent selectivity for other kinases, a good safety profile, and favorable pharmacokinetic properties for potential cancer immunotherapy use.
Article Synopsis
- Continuous glucose monitoring (CGM) may provide valuable glucose measurements for diabetic patients undergoing hemodialysis, but its accuracy compared to traditional blood glucose monitoring is unclear.
- The study involved 31 hemodialysis patients, measuring glucose levels with Dexcom G6 CGM and blood glucose periodically; results indicated moderate correlations and some differences in measurements.
- Despite CGM showing higher mean absolute relative differences than optimal thresholds, most values fell within clinically acceptable ranges, suggesting potential merit in using CGM for this patient group, but further research is necessary.