Publications by authors named "M Simonetto"
Background: Acute ischemic lesions seen on brain magnetic resonance imaging (MRI) are associated with poor intracerebral hemorrhage (ICH) outcomes, but drivers for these lesions are unknown. Rapid hemoglobin decrements occur in the initial days after ICH and may impair brain oxygen delivery. We investigated whether acute hemoglobin decrements after ICH are associated with MRI ischemic lesions and poor long-term ICH outcomes.
View Article and Find Full Text PDFProviding specialized care to critically ill neurology patients has improved outcomes for patients with neurological emergencies; however, there are still some gaps in neurocritical care (NCC) that offer opportunities for improvement. Among these gaps, improving education of the multidisciplinary NCC team, targeting individualized treatments for neurologically critically ill patients, and reducing disparities for undeserved patients as well as disadvantaged areas are priorities to advance the field. This review focuses on the current challenges neurointensivists face, including difficulties in neuroprognostication, ethical challenges in end-of-life care, and neuropalliative care.
View Article and Find Full Text PDFAging affects all organs. Arteries, in particular, are among the most affected. Vascular aging (VA) is defined as age-associated changes in function and structure of vessels.
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- The study investigates the link between red blood cell (RBC) concentrations, measured as hematocrit, and lacunar infarcts—small brain lesions related to ischemic stroke—using two groups: stroke-free adults and acute stroke patients.
- Results showed that in stroke-free older adults, there is a U-shaped relationship, meaning both low and high hematocrit levels are associated with chronic covert lacunar infarcts.
- In acute stroke patients, the study found a direct correlation where higher hematocrit levels were linked to an increased occurrence of acute lacunar strokes, suggesting that RBC concentrations might play a significant role in both chronic and acute brain injury.
Background: Intracerebral hemorrhage (ICH) is associated with an increased risk of ischemic stroke. Whether there are racial and ethnic disparities in the risk of ischemic stroke after ICH is poorly understood. We therefore aimed to test the hypothesis that non-Hispanic Black and Hispanic ICH patients have a higher risk of ischemic stroke compared with non-Hispanic White ICH patients.
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