Publications by authors named "M Simantov"
Background: Individualizing induction therapy based on immunological risk is crucial for optimizing outcomes in kidney transplantation.
Methods: A retrospective analysis included 157 first live-donor non-sensitized kidney transplant recipients (KTRs). Within this cohort, 96 individuals exhibited low human leukocyte antigen (HLA) matching (5-6 HLA mismatches).
Dosimetric Analyses of the Three Radiation Techniques Used in the EORTC 22922/10925 IM-MS Breast Cancer Trial.
Clin Oncol (R Coll Radiol)
November 2024
Article Synopsis
- The study compares dosimetry of three radiation therapy techniques for targeting internal mammary and supraclavicular nodes in breast cancer treatment, as part of the EORTC 22922/10925 trial.
- A retrospective analysis of ten randomly selected left-sided breast cases was conducted, assessing plans according to trial protocols, where doses to planning target volumes and organs at risk were measured.
- Results showed that while all techniques adequately dosed the breast and supraclavicular regions, the individualized plan had lower internal mammary coverage, but reduced heart exposure compared to standard techniques, suggesting benefits in treatment planning for breast cancer outcomes.
Dose escalation with simultaneous integrated boost for un-methylated multiple glioblastoma.
Rep Pract Oncol Radiother
July 2024
Background: Simultaneous involvement of multiple distinct brain regions occurs in 2-5% of all high-grade gliomas (HGG) and is associated with poor prognosis. Whereas radiotherapy (RT) is an important and well-established treatment for high-grade glioma, the role of dose-escalated radiotherapy has yet to be established. In this case series, we report upon the dosimetry, adverse effects, and response in patients with multiple un-methylated high-grade gliomas receiving dose-escalated radiation.
View Article and Find Full Text PDFIn the face of global adversities such as pandemics, military conflicts, and socio-political unrest, the resilience and well-being of populations can be severely tested. This study examines the fluctuating levels of distress within the Israeli population over a period of 2.5 years, encompassing events like the COVID-19 pandemic and various socio-political and security crises.
View Article and Find Full Text PDFBackground: Autosomal dominant polycystic kidney disease (ADPKD)-related end-stage kidney disease (ESKD) often necessitates transplantation. However, the impact of ADPKD on post-transplant outcomes, specifically hemoglobin levels, remains unknown.
Methods: We retrospectively analyzed 513 Kidney Transplant Recipients (KTRs), of whom 81 had ESKD due to ADPKD (20 with pre-transplant native nephrectomy and 61 without).