Publications by authors named "M Sigal"

Article Synopsis
  • - Cells without p53 signaling are common in ulcerative colitis (UC) and play a key role in the development of colorectal cancer linked to UC.
  • - Epithelial injury during colitis triggers stem cells to shift to a "fetal-like" regenerative state, which is regulated by p53 signaling during colitis but not during normal conditions.
  • - The study shows that while p53 is crucial in stopping excessive regeneration in healthy cells during injury, cells lacking p53 continue proliferating due to altered glycolysis processes, which helps explain their prevalence in UC and related cancers.
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Background: Primary sclerosing cholangitis (PSC) is associated with biliary obstructions that can require endoscopic retrograde cholangiopancreatography (ERCP). While the beneficial effects of ERCP are well documented, follow-up interventional strategies are less defined, and their long-term impact is debated.

Methods: We evaluated the outcome of a scheduled program of ERCP-guided interventions that have been developed and implemented at our tertiary liver center for more than 20 years.

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The increase in research funding for the development of antimalarials since 2000 has led to a surge of new chemotypes with potent antimalarial activity. High-throughput screens have delivered several thousand new active compounds in several hundred series, including the 4,7-diphenyl-1,4,5,6,7,8-hexahydroquinolines, hereafter termed dihydropyridines (DHPs). We optimized the DHPs for antimalarial activity.

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Article Synopsis
  • Retinol saturase (RetSat) plays a role in lipid metabolism and is found mainly in metabolic organs; its loss leads to increased body weight in mice.
  • When mice are fed a high-fat diet, RetSat levels in the intestine are upregulated, but deleting RetSat does not affect nutrient absorption; instead, it reduces body weight gain and fat mass.
  • In cases of colitis, where RetSat expression decreases, its ablation improves colon health, suggesting that RetSat may be a target for managing obesity and inflammatory bowel diseases.
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A subset of neuroendocrine tumors (NETs) can cause an excessive secretion of hormones, neuropeptides, and biogenic amines into the bloodstream. These so-called functional NETs evoke a hormone-related disease and lead to several different syndromes, depending on the factors released. One of the most common functional syndromes, carcinoid syndrome, is characterized mainly by over-secretion of serotonin.

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