Smartphone three-dimensional imaging for body composition assessment using non-rigid avatar reconstruction.

Background: Modern digital anthropometry applications utilize smartphone cameras to rapidly construct three-dimensional humanoid avatars, quantify relevant anthropometric variables, and estimate body composition.

Methods: In the present study, 131 participants ([73 M, 58 F] age 33.7 ± 16.

Body composition estimation from mobile phone three-dimensional imaging: evaluation of the USA army one-site method.

Within the USA military, monitoring body composition is an essential component of predicting physical performance and establishing soldier readiness. The purpose of this study was to explore mobile phone three-dimensional optical imaging (3DO), a user-friendly technology capable of rapidly obtaining reliable anthropometric measurements and to determine the validity of the new Army one-site body fat equations using 3DO-derived abdominal circumference. Ninety-six participants (51 F, 45 M; age: 23·7 ± 6·5 years; BMI: 24·7 ± 4·1 kg/m) were assessed using 3DO, dual-energy X-ray absorptiometry (DXA) and a 4-compartment model (4C).

Simultaneous evaluation of the imprecision and inconsistency domains of GRADE can be performed using prediction intervals.

Objectives: To explore the use of prediction interval (PI) for the simultaneous evaluation of the imprecision and inconsistency domains of Grading of Recommendations, Assessment, and Evaluation using stakeholder-provided decision thresholds.

Study Design And Setting: We propose transforming the PI of a meta-analysis from a relative risk scale to an absolute risk difference using an appropriate baseline risk. The transformed PI is compared to stakeholder-provided thresholds on an absolute scale.

Development of a high throughput oxidation profiling strategy for monoclonal antibody products.

Oxidation is one of the most common degradation pathways of biopharmaceutics, potentially leading to altered product stability, pharmacokinetics, reduced biological activity and/or an increased immunogenicity. However, it is often insufficiently assessed in early development stages, leaving potential molecule liabilities undiscovered. Aim of the present work was the development of a high throughput oxidation profiling strategy, applicable throughout various stages of biopharmaceutical development.