Diagnostic accuracy of an antigen-based point-of-care test versus nucleic acid amplification testing for genital trichomoniasis among pregnant women attending antenatal care facilities in Zambia.

Background: Infection with Trichomonas vaginalis (TV) is the most prevalent curable sexually transmitted infection (STI) globally and is associated with prelabour rupture of membranes, preterm delivery, and low birthweight. Point-of-care (POC) testing for TV during pregnancy may facilitate rapid antenatal case detection and treatment. This study, part of the World Health Organization's global ProSPeRo study, aimed to evaluate the performance of OSOM® Trichomonas Rapid Test, an antigen-based POC test, against a reference nucleic acid amplification test (NAAT) among pregnant women in Zambia.

Sero-epidemiology of measles Immunoglobulin G antibodies among newborn from South East Asia and sub-Saharan Africa: an observational, multicentre study.

Objectives: To investigate the transplacental acquisition of measles IgG in newborn at delivery in Bangladesh, Bhutan, India, Ethiopia, Mozambique, Kenya, Nigeria, Mali, and South Africa.

Methods: Archived cord serum, from a multi-center study on Group B Streptococcus, were tested for measles IgG using a commercial enzyme link immunosorbent assay (ELISA). We tested 323 randomly selected samples from each of the sites.

Isolated Canalicular Pseudoepitheliomatous Hyperplasia: New Disease Description, Clinical Spectrum, Proposed Management, and Outcomes.

Purpose: To define the clinical entity of "isolated canalicular pseudoepitheliomatous hyperplasia."

Methods: A retrospective interventional case series that included biopsy-proven cases of pseudoepitheliomatous hyperplasia of the canaliculi. Dacryoendoscopy was performed before the surgical procedure to determine the extent of the lesion.

Metagenomic Profile of the Lacrimal Sac Microbial Communities in Congenital Nasolacrimal Duct Obstruction: The Lacriome Paper 7.

Purpose: To study the metagenomics of microbes isolated from the lacrimal sacs of patients with congenital nasolacrimal duct obstruction (CNLDO).

Methods: A prospective study was performed on 10 consecutive lacrimal sac samples obtained for the metagenomic analysis from the patients with CNLDO who underwent endoscopic dacryocystorhinostomy at a tertiary care dacryology service. Immediately after a full-length lacrimal sac marsupialization, the samples were collected and transported on ice to the laboratory.

Efficacy and Safety of Recombinant Human Prourokinase in Acute Ischemic Stroke Within 4.5 h: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Background: Acute ischemic stroke (AIS) requires timely thrombolysis to restore perfusion and minimize neurological damage. Recombinant human prourokinase (rhPro-UK) has emerged as a promising alternative to alteplase, with potential efficacy and safety benefits within the critical 4.5-h treatment window.