A new method for removal of albumin-binding uremic toxins: efficacy of an albumin-dialysate.

It is difficult for conventional hemodialysis to remove albumin-binding uremic toxins (ABUTs) even though they are low molecular weight substances. We investigated the efficiency of albumin-dialysate (AD) for removal of ABUT. Phenols and indoxyl sulfate were selected as ABUT.

A case of thrombotic thrombocytopenic purpura refractory to plasma exchange.

We experienced a case of thrombotic thrombocytopenic purpura (TTP) finally relieved after 74 sessions of plasma exchange (PE). The patient was a 56-year-old male. In August 1999, he was examined in emergency because of brown urine and a lowered level of consciousness.

A case of factor VIII inhibitor-positive acquired hemophilia treated by plasmapheresis.

We report on a case of factor VIII inhibitor-positive acquired hemophilia in which combined therapy of plasma exchange (PE) and steroids was effective. The patient, a 68-year-old man, had undergone hemodialysis since April 1998, due to chronic renal failure caused by diabetic nephropathy. The hemostasis of blood access sites gradually became difficult after the initiation of dialysis and the prolongation of activated partial thromboplastin time (APTT) (74.

Effects of trapidil and suramin on growth factor-induced calcium response and tyrosine phosphorylation in human glioma cells.

Platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) induce the proliferation of glioma cells in vitro. Trapidil and suramin inhibit this growth factor-stimulated glioma cell growth, but the mechanisms are not fully understood. The effects of trapidil and suramin on PDGF- and EGF-induced early biochemical events in T98G cells were studied.

[Experimental study on secondary living bone graft--method of creating new donor by vascular bundle implantation to isolated bone].

The purpose of this study was to demonstrate the possibility of creating a new donor for a vascularized bone graft by a vascular bundle implantation to an isolated bone. Preliminary experiments on rats were performed preliminarily in order to investigate the revascularization of bone by a vascular bundle implantation and/or by implanting in muscular tissues (experiment-1). When a vascular bundle was implanted to the intramedullary cavity of an isolated bone and then the bone was implanted in muscular tissues, the isolated bone was more readily revascularized and revitalized than under other conditions.