Publications by authors named "M Shiotani"
Drug-induced convulsion is a serious concern in drug development, such that the convulsion liability of drug candidates must be evaluated in preclinical safety studies. However, information on the differences among species regarding their sensitivity to convulsions induced by convulsant drugs in humans remains limited. Here, we selected 11 test articles from several pharmacological classes and compared the sensitivities of three types of laboratory animal to convulsion.
View Article and Find Full Text PDFPurpose: This study compared the clinical outcomes of men with Klinfelter syndrome based on karyotype.
Methods: The authors analyzed the outcomes of microdissection testicular sperm extraction (micro-TESE) performed on 57 patients with Klinfelter syndrome (KS) at our clinic.
Results: The average ages of the non-mosaic and mosaic KS groups were 32.
Article Synopsis
- The study investigates the use of a heart rate variability (HRV) index derived from machine learning as a biomarker for drug-induced convulsions, focusing on its effectiveness with various convulsants.
- Different doses of convulsants and non-convulsants were administered to telemetry-implanted male subjects, and the convulsive potential was analyzed using HRV data and statistical methods.
- Findings suggested that the convulsive index increased for certain convulsants at lower doses, while the methodology has potential for predicting autonomic nervous activity fluctuations, although it may produce false positives.
Methanol extract of the Cnidium officinale Makino rhizome, which is used as a crude drug Cnidium Rhizome (Cnidii Rhizoma; "Senkyu" in Japanese) and is listed in the Japanese Pharmacopoeia XVIII, showed intracellular triglyceride metabolism-promoting activity in high glucose-pretreated HepG2 cells. Thirty-five constituents, including two new alkylphthalide glycosides, senkyunosides A (1) and B (2), and a neolignan with a new stereoisomeric structure (3), were isolated in the extract. Their stereostructures were elucidated based on chemical and spectroscopic evidence.
View Article and Find Full Text PDFObjective: Assisted reproductive technology (ART), especially frozen-thawed embryo transfer (FET) in a hormone replacement cycle (HRC), is a risk factor for placenta accreta spectrum (PAS). This study aimed to clarify the risk factors for PAS related to the maternal background and ART techniques in pregnancies achieved after FET in an HRC.
Study Design: We performed a case-control study in two tertiary perinatal centres in Japan.