Publications by authors named "M Shinoda"
Article Synopsis
- Glioblastoma (GB) is highly invasive, and the study investigates the origins and molecular characteristics of butterfly glioblastoma (bGB) by analyzing a cohort of 34 bGB patients alongside others from public datasets.
- The results show that bGB can arise from two distinct origins—corpus callosum (CC) and cerebral hemisphere—with unique molecular mutations and prognostic implications, particularly identifying the CC-type as having worse survival outcomes.
- The study emphasizes the need for further research to understand the clinical significance and differences between the identified bGB subtypes to enhance treatment strategies and patient care.
Objectives: The underlying mechanism of masseter muscle pain hypersensitivity by sustained masseter muscle contraction (SMMC) is not well understood. This study aimed to examine whether the activation of satellite glial cells in the trigeminal ganglion (TG) contributes to masseter muscle pain hypersensitivity induced by SMMC.
Methods: Electrodes were placed on the masseter muscle fascia of rats to induce strong contractions, by daily electrical stimulation.
Damage to the peripheral nerves of trigeminal ganglion (TG) neurons leads to intractable orofacial neuropathic pain through the induction of neuroinflammation. However, the details of this process are not yet fully understood. Here, we found that fibroblast-derived interleukin (IL)-33 was required for the development of mechanical allodynia in whisker pad skin following infraorbital nerve injury (IONI).
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- Age-related changes in macrophage polarization in the trigeminal ganglion (TG) contribute to increased sensitivity to intra-oral pain after mucosal incisions, particularly in older SAMP8 mice compared to younger SAMR1 mice.
- The study involved measuring pain thresholds and analyzing the presence of specific inflammatory macrophage types (M1 and M2) in the TG over a period of 21 days post-injury.
- Results showed that enhanced CCL2 signaling from M1-macrophages in older mice led to greater pain hypersensitivity, indicating a link between aging, macrophage activity, and prolonged pain response.
Objectives: Pharyngeal follicles similar to those seen in influenza have been observed in patients with coronavirus disease 2019 (COVID-19), suggesting their potential as early-stage diagnostic markers. In this study, we examined the diagnostic potential of pharyngeal follicles for COVID-19, particularly the Omicron variant and its subtypes, to obtain basic data for AI-based diagnostic imaging tools.
Methods: A cross-sectional study was conducted from July 21, 2022, to March 31, 2023, at the Tokyo Shinagawa Hospital's fever clinic.