Publications by authors named "M Shimoyama"
Article Synopsis
- Macropinocytosis is a key endocytic process that allows cells to take in fluids and particles, playing an essential role in various cell functions like nutrient uptake and signaling.
- While mostly studied in immune and cancer cells, the role of macropinocytosis in pathogens like Entamoeba histolytica, which causes amebiasis, is less understood.
- This study investigates the role of Rho small GTPase proteins in macropinocytosis of E. histolytica, revealing that the protein EhRacM enhances macropinocytosis and influences cell migration, highlighting its importance in understanding pathogen behaviors.
Article Synopsis
- Cronkhite-Canada syndrome (CCS) poses diagnostic challenges, necessitating endoscopic exams to check for chronic diarrhea, polyposis, and inflammation in polyps.* -
- A study highlighted seven CCS cases, involving four men and three women aged 48-72, all of whom were Asian, with chronic diarrhea as the main symptom.* -
- CCS carries a significant risk of malignant gastrointestinal conditions, particularly rectal cancer, requiring ongoing surveillance and monitoring through endoscopy.*
Calcification plays a key role in biological processes, and breakdown of the regulatory mechanism results in a pathological state such as ectopic calcification. We hypothesized that ENPP1, the enzyme that produces the calcification inhibitor pyrophosphate, is transcriptionally regulated by Nrf2, and that Nrf2 activation augments ENPP1 expression to inhibit ectopic calcification. Cell culture experiments were performed using mouse osteoblastic cell line MC3T3-E1.
View Article and Find Full Text PDFBackground: The activation of the antitumor immune responses of T cells and natural killer (NK) cells is important to induce breast tumor shrinkage via preoperative chemotherapy. We evaluated how antitumor immune responses contribute to the effects of such therapy.
Methods: Forty-three patients with stages I - IV breast cancer who underwent surgery between August 2018 and Jun 2023 after preoperative chemotherapy were enrolled.
Article Synopsis
- - The study evaluated the effectiveness of a person-centered care program for nurses in acute-care hospitals, comparing it to a dementia-type-specific program over a period from July 2021 to January 2022 across seven hospitals.
- - Out of 158 participants, those in the intervention group showed significant gains in dementia nursing expertise, medical knowledge, and confidence, along with improvements in ethical sensitivity regarding patient dignity.
- - The control group also had positive outcomes, particularly in providing care tailored to cognitive function, indicating that both programs have valuable impacts on nursing care in dementia patients.