Publications by authors named "M Shimizu"
Aims/introduction: This study aimed to evaluate and compare the effectiveness of oral semaglutide after adding to or switching from incretin-related drugs by assessing the changes in HbA1c and body weight (BW) in participants with type 2 diabetes in clinical settings.
Materials And Methods: A total of 368 participants were divided into groups according to antidiabetic medications before oral semaglutide treatment; incretin-related drug-naïve (naïve), switching from dipeptidyl peptide-4 inhibitors (DPP-4i) or glucagon-like peptide-1 receptor agonist (GLP-1 RA) groups. Adjusted mean changes in HbA1c and BW at 6 months after oral semaglutide administration were compared among the three groups.
Background And Aims: This study prospectively compared the diagnostic accuracies of the improved Attenuation Measurement (iATT) algorithm and the Controlled Attenuation Parameter (CAP) and assessed the interchangeability of iATT with magnetic resonance imaging-derived proton density fat fraction (MRI-derived PDFF).
Methods: Patients with chronic liver disease were prospectively enrolled and underwent iATT, CAP and MRI-derived PDFF measurements for hepatic steatosis evaluation. According to MRI-derived PDFF values, steatosis grades were categorised as steatosis (S)0 (< 5.
Metabolic mechanism of lignin-derived aromatics in white-rot fungi.
Appl Microbiol Biotechnol
December 2024
Article Synopsis
- White-rot fungi, like Phanerochaete chrysosporium, are essential for breaking down lignocellulosic biomass, which includes important components like cellulose, hemicellulose, and lignin, thus contributing to the carbon cycle.
- These fungi use various enzymes—such as lignin peroxidases and cytochrome P450 monooxygenases—to degrade lignin and its derivatives, though more research is needed to fully understand the metabolic pathways involved.
- The metabolic flexibility of these fungi allows them to adapt their enzyme production, specifically through the interplay of key pathways, enhancing their efficiency in degrading lignin for potential biotechnological applications.