Publications by authors named "M Sheu"
Article Synopsis
- The study examined the risk of multiple chronic conditions (multimorbidity) among colon cancer survivors using data from Taiwan's cancer registry.
- It found that the majority of the 13,209 survivors had no comorbidities, while a smaller percentage had mild or severe conditions.
- Higher scores on the Charlson Comorbidity Index (CCI) were linked to increased mortality risk, highlighting the need for better comorbidity management to enhance survival in patients, especially those with severe conditions.
This study presents the development of thiol-maleimide/thiol-thiol double self-crosslinking hyaluronic acid-based (HA) hydrogels for use as dermal fillers. Hyaluronic acid with varying degrees of maleimide substitution (10%, 20%, and 30%) was synthesized and characterized, and HA hydrogels were fabricated using two molecular weights of four-arm polyethylene glycol (PEG10K/20K)-thiol as crosslinkers. The six resulting HA hydrogels demonstrated solid-like behavior with distinct physical and rheological properties.
View Article and Find Full Text PDFBackground: Oral cancer is a malignant tumor of the oral cavity, with regulatory T cell (Treg) infiltration associated with poor prognosis. Ginkgolide B (GB) has demonstrated effects on lipid metabolism; however, its potential immunotherapeutic effects on oral cancer have not been elaborated.
Purpose: This study aimed to explore the immunotherapeutic effects of Ginkgolide B (GB) in oral cancer.
Purpose: Immunotherapy emerges as a promising frontier in cancer therapy and prevention. This study investigates the capacity of tumor-antigenic nanoparticles, specifically ovalbumin-tethered spiked virus-like poly(lactic-co-glycolic acid) nanoparticles (OVA-sVLNP), to effectively elicit humoral and cellular immune responses against tumors.
Methods: OVA-sVLNP were synthesized through thiol-maleimide crosslinking using a single emulsion method.
Article Synopsis
- Poly(L-lactic acid) (PLLA) can promote collagen production but may cause issues if not injected properly, leading to complications.
- A new composite microneedle device was created to deliver PLLA microspheres evenly into the skin, improving healing and reducing inflammation compared to traditional injection methods.
- This innovative system not only triggers quick collagen production but also supports long-term collagen growth, making it a safer and more effective anti-aging treatment option.