Publications by authors named "M Sheaff"
Anti-neutrophil cytoplasmic antibody-associated vasculitides (AAV) represent a heterogeneous multisystem group of disorders typified by necrotising inflammation of smaller blood vessels, classically yielding a pauci-immune, crescentic glomerulonephritis. Without prompt treatment, there is a significant risk of irreversible damage and ensuing renal impairment.Diagnosis is often challenging, exacerbated by the disorder's often vague and insidious presentation.
View Article and Find Full Text PDFThe morbidity and mortality from AL amyloidosis has significantly improved with the development of novel treatments. Daratumumab is a highly effective treatment for AL amyloidosis, but end-stage kidney disease is a common complication of this condition. Kidney transplantation is the ideal form of renal replacement therapy but has historically been contraindicated in this group of patients.
View Article and Find Full Text PDFArticle Synopsis
- Immunoglobulin G4-related disease is an inflammatory condition that can affect multiple organs, with the kidneys often showing signs of tubulointerstitial nephritis, and sometimes glomerular diseases like membranous nephropathy.
- A 67-year-old male presented with symptoms of nephrotic syndrome, including heavy proteinuria and low albumin levels, and was diagnosed with minimal change disease linked to the immunoglobulin G4-related disease after a kidney biopsy.
- The case illustrates the association between immunoglobulin G4-related disease and various kidney conditions, as well as the serious risks of complications from high-dose steroid treatments.
Context.—: Mesothelioma is an uncommon tumor that can be difficult to diagnose.
Objective.
Importance: Arginine deprivation using ADI-PEG20 (pegargiminase) combined with chemotherapy is untested in a randomized study among patients with cancer. ATOMIC-Meso (ADI-PEG20 Targeting of Malignancies Induces Cytotoxicity-Mesothelioma) is a pivotal trial comparing standard first-line chemotherapy plus pegargiminase or placebo in patients with nonepithelioid pleural mesothelioma.
Objective: To determine the effect of pegargiminase-based chemotherapy on survival in nonepithelioid pleural mesothelioma, an arginine-auxotrophic tumor.