Publications by authors named "M Shahrousvand"
A promising approach for wound treatment is using multilayer wound dressings that offer multifunctional properties. In this study, a bilayered electrospun/hydrogel gelatin-based scaffold integrated with honey and curcumin was developed to treat wounds under an in vivo study. The first layer consisted of an enzymatic cross-linked gelatin hydrogel containing honey and curcumin, which gelatin/PCL nanofibers reinforced.
View Article and Find Full Text PDFSkin, the largest organ of the human body, accounts for protecting against external injuries and pathogens. Despite possessing inherent self-regeneration capabilities, the repair of skin lesions is a complex and time-consuming process yet vital to preserving its critical physiological functions. The dominant treatment involves the application of a dressing to protect the wound, mitigate the risk of infection, and decrease the likelihood of secondary injuries.
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- * Researchers are developing a non-toxic wound dressing using natural materials and an enzyme that improves its mechanical properties and absorption rates.
- * This new hydrogel shows promising results in healing efficiency, reducing treatment time by half, enhancing tissue regeneration, and minimizing scarring compared to traditional methods.
In this study, we employed a combination of electrospinning and electrospray techniques to fabricate wound dressings with a particle-fiber structure, providing dual characteristics of oxygen-releasing and intrinsic antioxidant properties, simultaneously. The electrospun part of the dressing was prepared from a blend of polycaprolactone/gallic acid--gelatin (GA--GE), enabling intrinsic ROS scavenging. To the best of our knowledge, this is the first time that PCL/GA--GE was fabricated by electrospinning.
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- The research focuses on creating scaffolds using a hybrid of poly(ɛ-caprolactone) and poly(vinyl alcohol) to enhance the differentiation of stem cells into bone tissue, leveraging calcium and phosphate compounds for better results.
- Modified cockle shell nanopowder was integrated into the scaffold, with 7 wt % identified as the optimal amount to avoid agglomeration, and the final scaffold PCL50-PVA50-CS7 demonstrated desirable hydrophilicity and mechanical strength.
- Analysis showed that this scaffold supports mesenchymal stem cell differentiation into osteogenic cells, with accelerated mineral deposition observed within about 7 days, as confirmed by Alizarin red staining.