Publications by authors named "M Shahidullah"
Article Synopsis
- Rising antimicrobial resistance (AMR) in Salmonella Typhi poses a significant threat to typhoid treatment, especially in high-burden countries like Bangladesh, where long-term data is lacking.
- The study analyzed typhoid cases in Dhaka from 1999 to 2022, finding a decrease in multidrug resistance (MDR) from 38% to 17% and a drop in cotrimoxazole consumption, while resistance to ciprofloxacin remained high (>90%).
- With a noted decline in MDR, the research suggests that first-line antibiotics may be safely reintroduced for treating typhoid fever, pending further decreases in resistance rates.
Article Synopsis
- Extreme hyperbilirubinemia in newborns is a major issue in low- and middle-income countries like Bangladesh, leading to significant health risks, especially since many births occur at home without screening or treatment.
- A cluster randomized trial will involve 530 pregnant women in rural Bangladesh, where community health workers (CHWs) will screen and provide home treatment for newborns with jaundice, comparing results to traditional care methods.
- The study aims to determine if CHW-led home phototherapy can effectively increase treatment rates for neonatal hyperbilirubinemia, potentially allowing for similar programs in other low-income settings to improve newborn health outcomes.
Previously we showed hyperosmotic solution caused TRPV1-dependent NKCC1 activation in the lens by a mechanism that involved ERK1/2 signaling. In various tissues, integrins and the cytoskeletal network play a role in responses to osmotic stress. Here, we examined the association between integrins and TRPV1-dependent activation of NKCC1 in mouse lens epithelium.
View Article and Find Full Text PDFBackground: According to Bangladesh Demographic and Health Survey (2022), neonatal mortality, comprising 67% of under-5 deaths in Bangladesh, is significantly attributed to prematurity and low birth weight (LBW), accounting for 32% of neonatal deaths. Respiratory distress syndrome (RDS) is a prevalent concern among preterm and LBW infants, leading to substantial mortality. The World Health Organization (WHO) recommends bubble continuous positive airway pressure (bCPAP) therapy, but the affordability and accessibility of conventional bCPAP devices for a large number of patients become major hurdles in Bangladesh due to high costs and resource intensiveness.
View Article and Find Full Text PDFEarly and extended erythropoietin monotherapy after hypoxic ischaemic encephalopathy: a multicentre double-blind pilot randomised controlled trial.
Arch Dis Child Fetal Neonatal Ed
October 2024
Objective: To examine the feasibility of early and extended erythropoietin monotherapy after hypoxic ischaemic encephalopathy (HIE).
Design: Double-blind pilot randomised controlled trial.
Setting: Eight neonatal units in South Asia.