Publications by authors named "M Seynaeve"
Article Synopsis
- - The study aimed to investigate the effects of low-dose oral psilocybin, along with psychological support, on patients suffering from chronic short-lasting unilateral neuralgiform headache attacks (SUNHA), focusing on cognitive impact, safety, and headache severity.
- - Participants received ascending doses of psilocybin (5, 7.5, and 10 mg) over three sessions, but recruitment challenges limited the study to four enrolled patients, with only three completing it.
- - Results indicated no significant adverse effects, but cognitive function data could not be collected due to high subjective dose intensity, and headaches remained severe throughout the trial with minimal observed changes in headache frequency or severity.
The objective of this study was to evaluate and improve the prediction models of the AutoFOM III and FOM II apparatuses (Frontmatec Group, Denmark) used to estimate the lean meat percentage (LMP) of pig carcasses in Belgium, since the current models underestimate the pig carcasses with a LMP higher than 66 %. Non-linearity in the backfat thickness (BT) parameters was identified as the main reason for this bias in prediction. Box-Cox transformation of the parameters R2P10, R2P8 and R2P4 from AutoFOM III allowed to lower the root mean squared error of prediction (RMSEP) of the model from 1.
View Article and Find Full Text PDFAims: To investigate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of BPL-003, a novel intranasal benzoate salt formulation of 5-methoxy--dimethyltryptamine (5-MeO-DMT), in healthy participants.
Methods: In all, 44 psychedelic-naïve participants enrolled in the double-blind, placebo-controlled single ascending dose study (1-12 mg BPL-003). Concentrations of 5-MeO-DMT and its pharmacologically active metabolite, bufotenine, were determined in plasma and urine.
Background: Psychedelics have received renewed scientific attention in recent decades because of their potential to induce long-term changes in behaviour and cognition with potential therapeutic applications in various psychiatric indications.
Aim: To provide a brief overview of the neurobiological action of classical serotonergic psychedelics, their impact on neural networks and implications for potential clinical applications.
Method: We provide a non-exhaustive review of the current literature by subsequently and thematically outlining: 1.
Article Synopsis
- * Participants in the 25 mg group showed a significant reduction in depression scores after 3 weeks, with a mean change of -12.0, compared to -7.9 for 10 mg and -5.4 for the control group.
- * Although the higher dose showed benefits, many participants experienced adverse effects, including headache and nausea, and some reported suicidal thoughts, underscoring the need for further research.