Publications by authors named "M Seth Hochman"

Objectives: Currently, pedestrians' road-crossing decisions depend on the traffic at the crossing point, crossing opportunities, and circumstantial elements. Longer wait times on the curb and time pressure raise the number of traffic violations among pedestrians. The era of fully autonomous vehicles (FAVs) promises new interactions.

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Article Synopsis
  • * Four JAK inhibitors have been approved to manage MF symptoms, with allogeneic stem cell transplantation as a potential cure for higher-risk patients, although it's risky.
  • * Newer JAK inhibitors, like pacritinib and momelotinib, are designed to be more effective for patients with low platelet or red blood cell counts, and ongoing research aims to improve treatment outcomes through sequencing therapies and developing novel combinations.
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The transcription factor STAT3 drives the expression of genes promoting cellular proliferation, survival, and pluripotency. The description of STAT3 mutations and their clinical correlates in myeloid neoplasms, such as acute myeloid leukemia and myelodysplastic syndromes, raises new insights into both the pathogenesis and the targeted therapy of these diseases. See related article by Ye et al.

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Both clonal plasma cell and myeloid disorders occur more frequently with age. Patients with concurrent clonal plasma cell and myeloid disorders (CPCMD) can present clinical and therapeutic challenges. In this single-institution cohort of patients with CPCMD ( = 18), we abstracted clinically relevant themes.

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