Individualized, perioperative, hemodynamic goal-directed therapy in major abdominal surgery (iPEGASUS trial): study protocol for a randomized controlled trial.

Background: Postoperative morbidity and mortality in patients undergoing surgery is high, especially in patients who are at risk of complications and undergoing major surgery. We hypothesize that perioperative, algorithm-driven, hemodynamic therapy based on individualized fluid status and cardiac output optimization is able to reduce mortality and postoperative moderate and severe complications as a major determinant of the patients' postoperative quality of life, as well as health care costs.

Methods/design: This is a multi-center, international, prospective, randomized trial in 380 patients undergoing major abdominal surgery including visceral, urological, and gynecological operations.

[Renal adenocarcinoma in children. Report of a case].

Description of the accidental finding of a renal adenocarcinoma in a 10-year old boy, after abdominal trauma and with a good evolutive behaviour. The clinical, diagnostic, therapeutical and survival aspects are analyzed, including a literature update of a renal neoformation which shows lower paediatric incidence than Wilm's Tumour or Neuroblastoma.

Pharmacokinetics and pharmacodynamics of rocuronium bromide in adult patients.

In seven patients (M/F: 4:3) rocuronium 0.6 mg kg-1 was given after the induction of anaesthesia with propofol, and during maintenance with N2O/O2, halothane 0.5% and alfentanil 60-90 micrograms kg-1 h-1.

[Speed of intubation using a new neuromuscular blocker. Rocuronium bromide (ORG 9426)].

Objectives: To compare intubation conditions and neuromuscular parameters, patency time, maximum level of block, time and clinical duration of effect for rocuronium bromide 0.6 mg/kg (ORG 9426) versus equally potent doses of vecuronium and atracurium under similar experimental conditions.

Patients And Methods: Sixty patients were divided into three groups of twenty.

[Prevalence of human immunodeficiency virus infection, hepatitis B virus and syphilis in full term pregnancy].

Background: The estimation of the frequency of infection by HIV, hepatitis B virus and syphilis in unselected populations of full-term pregnancy is useful for epidemiologic surveillance of these diseases and for decision marking in prenatal detection.

Methods: A transversal study of 3,193 women who gave birth in the Hospital General de Elche between March 1989 and February 1990 was carried out. A blind survey was developed to avoid ethic problems and bias derived from the undertaking of HIV test without patient consent.