Publications by authors named "M Sene"
Purpose: The detection of circulating tumor DNA, which allows non-invasive tumor molecular profiling and disease follow-up, promises optimal and individualized management of patients with cancer. However, detecting small fractions of tumor DNA released when the tumor burden is reduced remains a challenge.
Experimental Design: We implemented a new highly sensitive strategy to detect base-pair resolution methylation patterns from plasma DNA and assessed the potential of hypomethylation of LINE-1 retrotransposons as a non-invasive multi-cancer detection biomarker.
Article Synopsis
- Head and neck squamous cell carcinoma (HNSCC) shows significant genetic diversity within tumors, complicating targeted treatment approaches and making traditional imaging ineffective for detecting minimal residual disease (MRD).
- A study of 41 patients with resectable HNSCC found that circulating tumor DNA (ctDNA) can serve as a biomarker for assessing tumor heterogeneity and MRD, with notable detection rates at surgery and recurrence.
- The presence of ctDNA shortly after surgery correlated with disease recurrence, providing an early warning about potential relapse, thus supporting its role in post-operative monitoring and precision medicine strategies.
Introduction: In-hospital mortality is a critical indicator of healthcare quality, although most hospital deaths result from unavoidable morbid processes.
Objectives: This study aimed to examine cardiovascular mortality in working-age patients by analysing epidemiological, clinical, and paraclinical characteristics and identifying the key etiological factors associated with mortality.
Methodology: A descriptive and analytical retrospective study was conducted from September 2019 to August 2022 at the General Hospital Idrissa POUYE in Dakar.
This study focuses on the synthesis of silver nanoparticles (AgNPs) using the extract of leaves. The extraction was done using maceration at room temperature in water for 48 h. The synthesized nanoparticles were characterized by IR, XRD, TEM, and SEM.
View Article and Find Full Text PDFCombretum micranthum (Combretaceae) is a medicinal plant widely known and used in Africa to treat a variety of conditions such as diabetes, fever, coughs, bronchitis, diarrhea, pain, malaria and liver disorders, among others. Due to its wide traditional use, in this review, published scientific reports on its composition and pharmacological properties were explored by conducting a literature search of databases. To date, 155 organic compounds including 34 flavonoids, 16 phenolic acids, 14 alkaloids, 15 fatty acids, 14 terpenoids/steroids, 24 amino acids, 8 carbohydrate substances and 30 other organic compounds have been identified from this plant.
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