Grignard Method for Preparing Thioesters from Esters and Its Application to One-Pot Synthesis of Ketones and Aldehydes.

A new protocol for preparing thioesters from the corresponding methyl esters was developed using PrMgCl and odorless 1-dodecanthiol, CHSH, under mild reaction conditions, during which in situ-generated CHSMgCl selectively reacted with the carbonyl group of esters. A variety of aromatic and aliphatic esters were readily converted in up to 99% yield with excellent functional group tolerance. Furthermore, based on the quantitative formation of the thioesters, we successfully applied our method to a one-pot synthesis of ketones and aldehydes from esters.

Large-cell neuroendocrine carcinoma of the kidney effectively treated by nivolumab and ipilimumab.

Introduction: Neuroendocrine tumors originating in the kidney are rare, and standard treatments are not established.

Case Presentation: An 80-years-old man was referred to our hospital with renal dysfunction and a left renal mass. Based on CT and bone scintigraphy results, he was diagnosed as having a large left renal tumor with a thrombus in the inferior vena cava, harboring lymph node, liver, lung, and left iliac bone metastasis.

Overexpression of plasmalemmal vesicle-associated protein-1 in patient with cyanotic nephropathy: a case report.

Background: Cyanotic nephropathy (CN) is a known complication of cyanotic congenital heart disease (CCHD). However, many aspects of its pathophysiology remain unclear.

Case Presentation: We report the case of a 29-year-old male with a history of tetralogy of Fallot.

Long-term treatment with the streptococcal exotoxin streptolysin O inhibits vascular smooth muscle contraction by inducing iNOS expression in endothelial cells.

Streptolysin O (SLO), a bacterial toxin produced by common hemolytic streptococci, including Streptococcus pyogenes and resident microbiota, may be associated with inflammation in the cardiovascular system. We previously reported that short-term treatment with SLO at relatively high concentrations (10-1000 ng/mL) diminished acetylcholine-induced, endothelial-dependent relaxation in a concentration-dependent manner. However, the vascular function effects of long-term exposure to SLO at lower concentrations are poorly understood.

Multiomics analysis unveils the cellular ecosystem with clinical relevance in aldosterone-producing adenomas with mutations.

Aldosterone-producing adenomas (APA), a major endocrine tumor and leading subtype of primary aldosteronism, cause secondary hypertension with high cardiometabolic risks. Despite potentially producing multiple steroid hormones, detailed cellular mechanisms in APA remain insufficiently studied. Our multiomics analysis focusing on APA with mutations, which represent the most common genetic form, revealed marked cellular heterogeneity.