Publications by authors named "M Seiler"
Introduction: The competency-based catalogue of learning objectives "Principal Relevant Objectives and Framework for Integrative Learning and Education in Switzerland" (PROFILES) based on Entrustable Professional Activities (EPAs) was newly introduced in 2018 in undergraduate medical education in Switzerland. Clerkships provide opportunities for students to train clinical skills and competencies within the curriculum. This study aims to assess the students' experiences during paediatric clerkships and whether they achieve the expected competency level of certain EPAs by the end of their training.
View Article and Find Full Text PDFIntroduction: Considering the significant role played by both intrinsic and extrinsic electric fields in the growth and maturation of the central nervous system, the impact of short exposure to external electric fields on the development and differentiation of retinal organoids was investigated.
Methods: Retinal organoids derived from human embryonic stem cells were used at day 80, a key stage in their differentiation. A single 60-minute exposure to a biphasic electrical field was administered to assess its influence on retinal cell populations and maturation markers.
In this randomized controlled trial, we assessed the non-inferiority of buddy taping to splinting after reduction of displaced extra-articular proximal and middle phalangeal finger fractures in children. The primary outcome was the rate of secondary fracture displacements; the secondary outcomes were patient comfort, analgesic efficacy and total range of active motion 6 months after injury. Eighty-one patients participated: 43 with taping and 38 with splinting.
View Article and Find Full Text PDFArticle Synopsis
- Deep generative modelling is a powerful tool increasingly used across various disciplines, particularly in healthcare to create solutions for medical challenges and personalized treatments, like digital twins of patients.
- The text introduces core concepts and popular approaches in generative modelling, focusing on their ability to generate synthetic data and represent observed data effectively.
- It reviews current applications in neuroimaging, specifically for Alzheimer's and multiple sclerosis, while also addressing challenges like computational needs, model evaluation, and privacy concerns for future research.
Article Synopsis
- * The MYTHIC Study is designed as a rigorous trial involving 13 Swiss pediatric centers, comparing macrolide treatment to placebo in children aged 3-17 diagnosed with pneumonia, using precise tests to confirm M. pneumoniae infection.
- * The main goals are to assess the time to stabilize vital signs and determine any changes in patient care within 28 days, with an aim to show that the placebo is not significantly less effective than macrolide treatment in managing this infection.