[Alloimmune thrombocytopenia in the newborn infant caused by maternal PlA1 antibodies].

The case of pregnant woman, whose first child was born with neonatal alloimmune thrombocytopenia (NATP) and PlA2/PlA1 constellation, is used as an example to draw up a programme for the care of pregnant women whose children are expected to be born with NATP. In one of 2,000 to one of 3,000 cases, the PlA1-positive foetal platelets cause a sensitization of the PlA1-negative mother. Transplacental passage of maternal IgG alloantibodies leads to accelerated destruction of foetal platelets.

[Use of a microtest plate method in pregnancy thrombocyte serology].

In search of a time saving concept for verifying a neonatal allo-immune thrombocytopenia (NATP) we tested the suitability of a solid phase platelet assay for antibodies (ab) which might induce NATP. Compared to PSIFT the test is equally appropriate for the detection of platelet specific and HLA ab. Using maternal, paternal, P1A1 neg.

Effect of blood donations on the profile of lymphocytic cells.

The effect of ordinary blood donation and repeat leukapheresis procedures on the profile of lymphocytic cells in peripheral blood was assessed. In ordinary blood donors blood donation was found to have no effect on serum Ig levels and peripheral lymphocyte populations. The removal of leukocytes and serum Ig during leukapheresis lead to a significant decrease of serum IgG and IgM and of all lymphocytic cell parameters, O cells being the only exception.