Publications by authors named "M Segondy"
Background: We studied the duration of HPV detection and risk of (re-) detection for 25 HPV genotypes in a cohort of 132 women followed every eight weeks for up to two years between 2016 and 2020. Participants were between 18 and 25 years old at inclusion and half of them were vaccinated against HPV. They were recruited near the University and the STI detection centre in Montpellier, France.
View Article and Find Full Text PDFHuman papillomaviruses (HPVs), the most oncogenic virus known to humans, are often associated with Herpes Simplex Virus-2 (HSV-2) infections. The involvement of the latter in cervical cancer is controversial but its long-term infections might modulate the mucosal microenvironment in a way that favors carcinogenesis. We know little about coinfections between HSV-2 and HPVs, and studying the immunological and microbiological dynamics in the early stages of these infections may help identify or rule out potential interactions.
View Article and Find Full Text PDFThe vaginal ecosystem is a key component of women's health. It also represents an ideal system for ecologists to investigate the consequence of perturbations on species diversity and emerging properties between organizational levels. Here, we study how exposure to different types of menstrual products is linked to microbial, immunological, demographic, and behavioural measurements in a cohort of young adult women who reported using more often tampons (n = 107) or menstrual cups (n = 31).
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the prevalence of anal HPV and high-grade squamous intraepithelial lesions (HSIL) in men, focusing on factors like HIV status and sexual orientation.
- Researchers conducted a systematic review and pooled individual data from 64 studies involving nearly 29,900 men to analyze type-specific HPV infection and HSIL occurrences.
- Findings showed varying HPV prevalence rates: among HIV-negative MSW, HPV16 was at 1.8%, while HIV-positive MSM had rates as high as 28.5% for HPV16 and 74.3% for high-risk types, suggesting a significant impact of HIV on HPV infection rates.
Article Synopsis
- The study assessed various cervical cancer screening methods in women living with HIV in Africa, focusing on their diagnostic accuracy for detecting precancerous conditions.
- It involved 1,238 women aged 25-50 from Burkina Faso and South Africa, comparing methods like visual inspection and HPV DNA tests, and found significant differences in sensitivity and prevalence of high-grade cervical lesions.
- The results indicated that High-risk HPV testing (HC2) showed much better sensitivity for detecting precancer compared to visual inspection methods, highlighting the need for targeted screening strategies in WLHIV.