Publications by authors named "M Seferoglu"
Objective: This study aimed to conduct a unified analysis comparing the clinical characteristics, disease progression, and treatment responses of pediatric-onset multiple sclerosis (POMS), adult-onset multiple sclerosis (AOMS), and late-onset multiple sclerosis (LOMS) patients.
Methods: Utilizing a retrospective cohort design, we analyzed the records of 269 patients from MS clinics and categorized them into the POMS (<18 years), AOMS (≥18 and <50 years), and LOMS (≥50 years) groups based on age at diagnosis. Data collection focused on demographics, clinical manifestations, disability scores, MRI findings, and treatment outcomes.
Background: Ocrelizumab (OCR) effectively modifies the disease course in multiple sclerosis (MS) patients but may cause a preinfusion "wearing-off phenomenon" (WoP). This study explored the prevalence, timing, and severity of this phenomenon in MS patients using the OCR, as well as the associated symptoms and treatment satisfaction.
Methods: We conducted a prospective multicenter study across 11 MS centers involving MS patients aged 18-70 years who had received at least two OCR doses.
The Effects of Photobiomodulation Therapy in Cubital Tunnel Syndrome, Clinical Trial.
Photobiomodul Photomed Laser Surg
November 2024
Article Synopsis
- The study evaluated the effects of laser therapy combined with splints and exercise on patients with cubital tunnel syndrome (CuTS) compared to a placebo treatment.
- A total of 64 patients were randomly divided into two groups, one receiving actual laser therapy and the other receiving sham laser therapy, alongside standardized treatments like splints and exercises.
- Results showed significant short-term improvements in pain and function for the laser therapy group compared to the placebo, but both groups had similar medium-term effects, suggesting the need for more research with larger sample sizes.
Background: Cerebrospinal fluid (CSF) biomarkers provide critical insights into the pathophysiology and progression of multiple sclerosis (MS), as this study aimed to investigate the relationships between CSF oligoclonal band (OCB) counts and the clinical course and short-term prognosis of MS patients.
Methods: A retrospective cohort analysis covering a five-year period was conducted at two MS centers. Data on demographics, clinical presentation, MRI findings, EDSS scores, annualized relapse rate (ARR) in the first two years, and CSF analyses were analyzed.
Article Synopsis
- * The initiative has formed four working groups aimed at enhancing research, clinical management, eHealth, and healthcare system reforms, ensuring a collaborative effort among patients, caregivers, and other stakeholders.
- * As it progresses, the initiative plans to boost the use of eHealth tools and passive PROs in research and clinical settings, while also refining statistical methods in clinical trials and fostering alignment among industry, regulatory bodies, and health policymakers regarding PROs in MS healthcare.