Publications by authors named "M Scully"
Objective: To assess adolescents' baseline knowledge of smoking health harms scheduled to be covered in future graphic health warnings (GHWs) and inform the content of future tobacco control public communication campaigns.
Methods: Cross-sectional survey of 8631 secondary school students (mean age=14.5 years) in Australia in 2022/2023 (weighted n=8655).
The last decade has seen the introduction of two new licensed therapies for thrombotic thrombocytopenic purpura (TTP)-caplacizumab and recombinant ADAMTS 13 (rADAMTS 13), for immune (iTTP) and congenital TTP (cTTP) respectively. They improve acute TTP outcomes, reduce the need for plasma therapy, time to clinical response and treatment burden. Future pathways need to replace plasma exchange in acute TTP and optimise/personalise rADAMTS 13 in cTTP.
View Article and Find Full Text PDFDemystifying autoimmune HIT: what it is, when to test, and how to treat.
Hematology Am Soc Hematol Educ Program
December 2024
Article Synopsis
- Antibodies to platelet factor 4 (PF4) are mainly associated with classical heparin-induced thrombocytopenia (cHIT), while a new condition called vaccine-induced thrombocytopenia and thrombosis (VITT) has emerged related to COVID-19 vaccines.
- Differentiation between heparin-dependent and heparin-independent anti-PF4 conditions has led to the development of a rapid anti-PF4 assay that is not affected by heparin.
- VITT-like disorders, which present independently of heparin and are often triggered by infections or certain surgeries, are rare but associated with high mortality and require specific treatment approaches like immunomodulation therapy.
Background: Depression alleviation following treatment with repetitive transcranial magnetic stimulation (rTMS) tends to be more effective when TMS is targeted to cortical areas with high (negative) resting state functional connectivity (rsFC) with the subgenual anterior cingulate cortex (sgACC). However, the relationship between sgACC-cortex rsFC and the TMS-evoked response in the sgACC is still being explored and has not yet been established in depressed patients.
Objectives: In this study, we investigated the relationship between sgACC-cortical (site of stimulation) rsFC and induced evoked responses in the sgACC in healthy controls and depressed patients.