Publications by authors named "M Scotta"
Effectiveness of BNT162b2 and CoronaVac against COVID-19-related severe outcomes among children and adolescents: A Brazilian nationwide cohort study.
Vaccine
January 2025
Introduction: Nationwide databases from large countries may provide real-world evidence about COVID-19 vaccine effectiveness (VE). This study sought to assess the VE of BNT162b2 and CoronaVac against COVID-19-related severe outcomes in school-aged children and adolescents during the Omicron wave of the COVID-19 pandemic in Brazil.
Methods: A nationwide population-based cohort study compared the incidence risk ratios (IRRs) of hospitalization due to COVID-19-associated severe acute respiratory syndrome (SARS), need for invasive ventilatory support, and death among school-aged children (age 5 to 11 years) and adolescents (age 12 to 17 years), stratified by vaccination status (none, one, or two doses), in 2022.
Article Synopsis
- * A total of 1,644 individuals participated, with a pneumococcal carriage rate of 14.9%, and the most common serotype identified was 19A, indicating a significant presence of non-vaccine serotypes.
- * The findings suggest a need for ongoing monitoring of pneumococcal serotypes, as many prevalent ones are not covered by existing vaccines, highlighting potential implications for public health policies.
Article Synopsis
- The study analyzed the seasonality of acute bronchiolitis hospitalizations in infants in Brazil from 2020 to 2022, comparing it with data from previous years.
- The research found a dramatic 97% decrease in hospitalizations during strict COVID-19 measures but a subsequent 95% rise after these measures were relaxed, leading to an overall 16% increase in hospitalizations.
- In 2022, the seasonal pattern for acute bronchiolitis re-emerged, peaking in May, indicating a significant relationship between COVID-19 interventions and respiratory illnesses in young children.
Background: Persistent symptoms and exercise intolerance have been reported after COVID-19, even months after the acute disease. Although, the long-term impact on exercise capacity and health-related quality of life (HRQoL) is still unclear.
Research Question: To assess the long-term functional capacity and HRQoL in patients hospitalized due to COVID-19.