Investigations on the Performance of a 5 mm CdTe Timepix3 Detector for Compton Imaging Applications.

Nuclear power plant decommissioning requires the rapid and accurate classification of radioactive waste in narrow spaces and under time constraints. Photon-counting detector technology offers an effective solution for the quick classification and detection of radioactive hotspots in a decommissioning environment. This paper characterizes a 5 mm CdTe Timepix3 detector and evaluates its feasibility as a single-layer Compton camera.

Structural and functional determination of peptide versus small molecule ligand binding at the apelin receptor.

We describe a structural and functional study of the G protein-coupled apelin receptor, which binds two endogenous peptide ligands, apelin and Elabela/Toddler (ELA), to regulate cardiovascular development and function. Characterisation of naturally occurring apelin receptor variants from the UK Genomics England 100,000 Genomes Project, and AlphaFold2 modelling, identifies T89 as important in the ELA binding site, and R168 as forming extensive interactions with the C-termini of both peptides. Base editing to introduce an R/H168 variant into human stem cell-derived cardiomyocytes demonstrates that this residue is critical for receptor binding and function.

Effects of a sorbitol-containing additive fed to dairy cows for 30 days postpartum.

The objective of this study was to determine the effects of early postpartum supplementation of Rally®, a sorbitol-containing feed additive (RAL), on lactation performance and automatic milking system (AMS) metrics on a commercial dairy farm. Multiparous (MT) and primiparous (PP) Holstein cows were randomly assigned to either RAL supplementation (570 g/d RAL; RAL-MT, n = 75, RAL-PP, n = 34) or control (CTL-MT, n = 72; CTL-PP, n = 38). The RAL cows were supplemented from 1 to 30 d in milk via an automated feed dispenser in the AMS.

Crowd-counting technology within the Smart City context: understanding, trust, and acceptance.

In city centers worldwide, including the UNESCO World Heritage Site of Bamberg's old town in Germany, alleviating pedestrian overcrowding is a pressing concern. Leveraging crowd-counting technologies with real-time data collection offers promising solutions, yet poses challenges regarding data privacy and informed consent. This preregistered study examines public response to a Smart City Bamberg project aimed at addressing pedestrian congestion through crowd-counting methods.

Small cell transformation in EGFR-mutated non-small cell lung cancer: DLL3 expression and efficacy of immune checkpoint inhibitors or tyrosine kinase inhibitors combined with chemotherapy.

Introduction: Small cell transformation (SCT) is a typical mechanism of adaptive resistance to third generation epidermal growth factor receptor inhibitors (EGFRi) which have become the standard of care for EGFR-driven non-small cell lung cancer (EGFR+ NSCLC). Little is known about the optimal management of SCT patients. This study aimed to compare outcomes under platinum/etoposide chemotherapy alone (chemo) or in combination with EGFR inhibitors (EGFRi+chemo) or immune checkpoint inhibitors (ICI+chemo).