Publications by authors named "M Schmuth"
Sporadic hidradenitis suppurativa (spHS) is a multifactorial disease in which genetic predisposition is intertwined with environmental factors. Owing to the still-to-date limited knowledge of spHS genetics, we calculated polygenic scores (PGSs) to study the genetic underpinnings that contribute to spHS within European demographic. A total of 256 patients with spHS and 1686 healthy controls were analyzed across 6 European clinical centers.
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- UV irradiation can lead to mutations that increase the risk of skin cancers, such as melanoma, with high doses causing inflammation and acute sunburn characterized by cell death.
- This study focused on Langerhans cells (LC) in the skin, investigating their role in the immune response following intense UVB exposure in mice.
- Findings revealed that LC activation was linked to increased inflammation and programmed cell death in damaged skin cells, highlighting their importance in managing UV-induced skin damage and potential cancer risk.
Exudates of nonhealing wounds contain drivers of pathogenicity. We utilized >800 exudates from nonhealing and healing wounds of diverse etiologies, collected by 3 different methods, to develop a wound-specific, cell-based functional biomarker assay. Human dermal fibroblast proliferation served as readout to (i) differentiate between healing and nonhealing wounds, (ii) follow the healing process of individual patients, and (iii) assess the effects of therapeutics for chronic wounds ex vivo.
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