Differentiation of Related Events in Hippocampus Supports Memory Reinstatement in Development.

Adults are capable of either differentiating or integrating similar events in memory based on which representations are optimal for a given situation. Yet how children represent related memories remains unknown. Here, children (7-10 years old) and adults formed memories for separate yet overlapping events.

A month in review: longitudinal dynamics between daily PTSD symptom networks, affect, and drinking behaviors in female college students.

Introduction: Sexual victimization (SV) is common among college women, with approximately half of those who have experienced SV meeting criteria for posttraumatic stress disorder (PTSD) within a year. Both SV and PTSD are associated with alcohol misuse among college women, often explained by the self-medication hypothesis. Existing literature focuses on overall PTSD severity rather than potential day-to-day fluctuations in specific symptoms, which might play a crucial role in understanding alcohol misuse risk.

Developmental refinements to neural attentional state during semantic memory retrieval through adolescence.

Despite the fact that attention undergoes protracted development, little is known about how it may support memory refinements in childhood and adolescence. Here, we asked whether people differentially focus their attention on semantic or perceptual information over development during memory retrieval. First, we trained a multivoxel classifier to characterize whole-brain neural patterns reflecting semantic versus perceptual attention in a cued attention task.

Metabolic control of adaptive β-cell proliferation by the protein deacetylase SIRT2.

Selective and controlled expansion of endogenous β-cells has been pursued as a potential therapy for diabetes. Ideally, such therapies would preserve feedback control of β-cell proliferation to avoid excessive β-cell expansion and an increased risk of hypoglycemia. Here, we identified a regulator of β-cell proliferation whose inactivation results in controlled β-cell expansion: the protein deacetylase Sirtuin 2 (SIRT2).

Anterior Hippocampal Engagement during Memory Formation Predicts Subsequent False Recognition of Similar Experiences.

People better remember experiences when they orient to meaning over surface-level perceptual features. Such an orientation-related memory boost has been associated with engagement of both hippocampus (HPC) and neocortex during encoding. However, less is known about the neural mechanisms by which a cognitive orientation toward meaning might also promote memory errors, with one open question being whether the HPC-a region traditionally implicated in precise memory formation-also contributes to behavioral imprecision.