Publications by authors named "M Scherg"

For the analysis of simultaneous EEG-fMRI recordings, it is vital to use effective artifact removal tools. This applies in particular to the ballistocardiogram (BCG) artifact which is difficult to remove without distorting signals of interest related to brain activity. Here, we documented the use of surrogate source models to separate the artifact-related signals from brain signals with minimal distortion of the brain activity of interest.

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Describing the location of EEG abnormalities, such as interictal epileptiform discharges, is an important step in the interpretation of EEG recordings and has clinical relevance, as it is expected to point out the region of the brain generating these abnormal signals. Traditionally, the location is reported by specifying the area on the scalp where maximum negativity is located. However, this only reflects the correct localization in the brain when the cortical generator is located on the convexity (radial orientation).

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Article Synopsis
  • The study aimed to validate relative source power (RSP) imaging for identifying extratemporal interictal epileptiform discharges (IEDs) in patients with focal epilepsy.
  • RSP maps demonstrated a higher accuracy in localizing epileptogenic lesions compared to conventional methods like voltage maps, showing matching results in 88% of cases.
  • The findings suggest that RSP imaging can be a quick and effective tool for improving the diagnosis and treatment of extratemporal focal epilepsy.
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Objective: To define and validate criteria for accurate identification of EEG interictal epileptiform discharges (IEDs) using (1) the 6 sensor space criteria proposed by the International Federation of Clinical Neurophysiology (IFCN) and (2) a novel source space method. Criteria yielding high specificity are needed because EEG over-reading is a common cause of epilepsy misdiagnosis.

Methods: Seven raters reviewed EEG sharp transients from 100 patients with and without epilepsy (diagnosed definitively by video-EEG recording of habitual events).

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In contrast to many neuroimaging modalities, clinical interpretation of EEG does not take advantage of post-processing and digital signal analysis. In most centers, EEG is still interpreted at sensor level, exactly as half a century ago. A major task in clinical EEG interpretation is the identification of interictal epileptiform discharges (IEDs).

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