Publications by authors named "M Scenna"
Type 2 diabetes mellitus (T2D) is defined by chronic hyperglycemia due to insufficient insulin secretion or activity and decreased insulin sensitivity, known as insulin resistance (IR). This condition leads to oxidative stress and inflammation, increasing the risk of systemic inflammatory diseases. Obesity and a sedentary lifestyle are major risk factors for IR and T2D.
View Article and Find Full Text PDFNeurological disorders are the second cause of death and the leading cause of disability worldwide. Unfortunately, no cure exists for these disorders, but the actual therapies are only able to ameliorate people's quality of life. Thus, there is an urgent need to test potential therapeutic approaches.
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- The study assessed the effectiveness and side effects of docetaxel as a pre-surgery chemotherapy for patients with advanced cervical cancer, enrolling 38 untreated patients aged 25-66 over a span from 1998 to 2000.
- Results showed an overall objective response rate of 34%, with 1 patient achieving a complete response and 11 achieving partial responses, while some patients experienced no change or progressive disease.
- The treatment's primary toxicity included high rates of leukopenia, neutropenia, and myalgias, with significant side effects, but no severe hypersensitivity reactions were observed.
A phase II trial was performed to assess the efficacy and toxicity of a combination of ifosfamide (IFX), cisplatin (CDDP), and vinorelbine (VNB) as neoadjuvant chemotherapy (NAC) for untreated advanced cervical carcinoma (ACC). Between October 1995 and February 1998, 40 patients were entered in this study. Their median age was 43 years (range: 23-74 years).
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