Publications by authors named "M Scarborough"
: The microbiological profile of bone and joint infections is important for determining the empiric choice of both systemic and local antimicrobial therapy. This study assessed whether there was a difference in the bacterial species that were isolated on culture in osteomyelitis (OM), fracture-related infection (FRI) or prosthetic joint infection (PJI). This was a retrospective, observational cohort study of patients who had surgical intervention for PJI or OM or FRI with a positive microbial culture between 2019 and 2022.
View Article and Find Full Text PDFBackground: Prior work has demonstrated that telemedicine in orthopedic surgery is cost-effective and can yield good clinical outcomes with high patient satisfaction. However, few studies have investigated the use of telemedicine in orthopedic oncology. In this study, we assessed the effect of telemedicine on (1) potential cost savings for orthopedic oncologic patients and (2) clinical outcomes as measured by unexpected in-person clinic visits and missed complications.
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- Short-chain fatty acids (SCFAs), which have an anti-inflammatory effect, are reduced in multiple sclerosis (MS), with unclear reasons for their depletion in the gut microbiome.* -
- In a study using a model for MS, it was found that certain gut bacteria can worsen symptoms by depleting SCFA-producing microbes and that increased dietary fiber can help counteract this effect.* -
- This research suggests that managing SCFA levels in MS patients may need a combination of dietary changes and adjustments to the gut microbiome to improve health outcomes.*
Article Synopsis
- A study was conducted to compare the effectiveness of local antibiotic treatment using aminoglycoside alone versus a combination of aminoglycoside and vancomycin in patients undergoing surgery for bone infections.
- Out of 266 patients, 252 completed the study, showing similar therapy failure rates of 8.8% for aminoglycoside alone and 8.6% for the combination treatment, indicating no significant benefit to adding vancomycin.
- Factors like higher BACH scores and low body mass index (BMI) were associated with an increased risk of treatment failure, but the method of antibiotic delivery and the presence of aminoglycoside resistance did not affect outcomes.
Article Synopsis
- Prosthetic joint infections (PJIs) caused by Candida species are serious complications following joint replacement surgeries, with a study reviewing 269 cases between 2010 and 2021 to assess treatment outcomes.
- The majority of infections occurred in older patients (average age 73), primarily in hips and knees, and most cases involved additional bacterial infections; roughly 58% achieved a cure at the two-year follow-up.
- Treatment effectiveness varied significantly depending on the surgical method used, with poorer outcomes linked to the debridement, antibiotics, and implant retention (DAIR) approach and patients older than 70, while infections from Candida parapsilosis tended to have better outcomes.