Identification of a major QTL conferring resistance to derived from the winter wheat 'Hokkai 240' on chromosome 2AS.

Wheat yellow mosaic disease is a soilborne disease caused by (WYMV). Symptoms include yellow mosaic coloring of leaves, stunting, and growth inhibition. Here we conducted a detailed analysis of resistance to this virus in winter wheat 'Hokkai 240' by carrying out inoculation tests of WYMV and conducting field tests.

Isosteric Replacement of Ester Linkage of Lysophospholipids with Heteroaromatic Rings Retains Potency and Subtype Selectivity.

Our group has reported various derivatives of lysophosphatidylserine (LysoPS) as potent and subtype-selective agonists for G-protein-coupled receptors (GPCRs). However, the ester linkage between the glycerol moiety and fatty acid or fatty acid surrogate is present in all of them. In order to develop these LysoPS analogs as drug candidates, appropriate pharmacokinetic consideration is essential.

Item response theory analysis of the University Personality Inventory in medical students.

Aim: Young adulthood has been recognized as an important period for the transition from adolescence to adulthood. The University Personality Inventory (UPI), a mental health questionnaire for young adulthood, is widely used to screen university students in East Asia. However, dichotomous systems do not allow respondent choose responses other than two options on each symptom.

Exploration of LPS agonist binding modes using the combination of a new hydrophobic scaffold and homology modeling.

Lysophosphatidylserine (LysoPS) is an endogenous pan-agonist of three G-protein coupled receptors (GPCRs): LPS/GPR34, LPS/P2Y, and LPS/GPR174, and we previously reported a series of LysoPS-based agonists of these receptors. Interestingly, we found that LPS agonist activity was very sensitive to structural change at the hydrophobic fatty acid moiety, whereas LPS agonist activity was not. Here, to probe the molecular basis of LPS agonist binding, we developed a new class of hydrophobic fatty acid surrogates having a biphenyl-ether scaffold.