Acute severe ulcerative colitis: defining the precise moment for colectomy.

Introduction: Acute severe ulcerative colitis (ASUC) is a critical manifestation of ulcerative colitis (UC), often necessitating colectomy when medical management fails. Despite advancements in therapeutic interventions such as corticosteroids, biologics, and JAK inhibitors, a significant proportion of patients require surgery, with colectomy rates ranging from 10% to 15%.

Areas Covered: This paper reviews the factors influencing the timing and necessity of colectomy in ASUC management, emphasizing the importance of multidisciplinary decision-making involving gastroenterologists and surgeons.

Accuracy prompts protect professional content moderators from the illusory truth effect.

Content moderators review problematic content for technology companies. One concern is that repeated exposure to false claims could cause moderators to come to believe the very claims they are supposed to moderate, via the "illusory truth effect." In a first lab-in-field experiment ( = 199) with a global content moderation company, we found that exposure to false claims while working as moderators increased subsequent belief among (mostly Indian and Philippine) employees by 7.

Stilbene Treatment Reduces Stemness Features in Human Lung Adenocarcinoma Model.

Lung cancer is among the most clinically challenging tumors because of its aggressive proliferation, metastasis, and the presence of cancer stem cells (CSCs). Natural bioactive substances have been used for cancer prevention, and, in particular, resveratrol (RSV), a stilbene-based compound with wide biological properties, has been proposed for chemoprevention. Its lesser-known analogue 4,4'-dihydroxy-trans-stilbene (DHS) has demonstrated superior activity both in cell-based assays and in mouse and zebrafish in vivo models.

A proteasome-dependent inhibition of SIRT-1 by the resveratrol analogue 4,4'-dihydroxy-stilbene.

Background And Aim: Resveratrol (RSV), is a stilbene-based compound exerting wide biological properties. Its analogue 4,4'-dihydroxy--stilbene (DHS) has shown improved bioavailability and antiproliferative activity and . One of the hypotheses on how resveratrol works is based on SIRT1 activation.

Erratum: The cognitive adaptability and resiliency employment screener (CARES): tool development and testing.

[This corrects the article DOI: 10.3389/fpsyt.2023.