Publications by authors named "M Sassoe-Pognetto"
Background: The choroid plexus (ChP) is the secretory epithelial structure located in the brain ventricles. Choroid plexus tumors (CPTs) are rare neoplasms predominantly occurring in young patients with intensified malignancy in children. CPT treatment is hindered by insufficient knowledge of tumor pathology and the limited availability of valid models.
View Article and Find Full Text PDFFibrosis is a marker of chronic kidney disease (CKD) and consists of the accumulation of the extracellular matrix (ECM) components, causing the progressive deterioration of kidney function. Human liver stem cells (HLSCs) have anti-fibrotic activity, and HLSC-derived extracellular vesicles (EVs) mediate this effect. Herein, we evaluated the ability of HLSC-EVs to reverse renal and cardiac alterations in a murine model of partial nephrectomy (PNx) that mimics human CKD development.
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- Viper bites are rare but can lead to serious complications, especially in children due to their smaller size; local symptoms include swelling, and severe cases can cause compartment syndrome.
- A case involving a 6-year-old girl in Italy illustrates the potential dangers, as she developed compartment syndrome from multiple viper bites and needed emergency surgery and antivenom treatment.
- The case emphasizes the need for quick assessment of snakebite severity and timely antivenom administration, with multiple bite marks potentially indicating more serious outcomes.
Article Synopsis
- * Researchers used a combination of advanced techniques, including CRISPR and phosphoproteomics, to study how neuroligin-3 localizes to different types of synapses in mouse and human brains.
- * Findings revealed that neuroligin-3 is region-specific, mainly found in excitatory synapses in the cortex and inhibitory synapses in subcortical areas, with its localization regulated by phosphorylation, affecting its interactions with other synaptic proteins.
Choroid plexuses (ChPs) produce cerebrospinal fluid and sense non-cell-autonomous stimuli to control the homeostasis of the central nervous system. They are mainly composed of epithelial multiciliated cells, whose development and function are still controversial. We have thus characterized the stepwise order of mammalian ChP epithelia cilia formation using a combination of super-resolution-microscopy approaches and mouse genetics.
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