Age-related changes in the D-aspartic acid content of the cranial bones in senescence-accelerated mice (SAM).

We measured the age-related changes in the D/L-aspartic acid ratio (D/L ratio) of cranial bones in two different sublines of senescence-accelerated mice (SAM/Iw): SAMP2/Iw (SAM, prone 2/Iwate) and SAMR1/Iw (SAM, resistant 1/Iwate). In SAM/Iw under 9 months of age, the D/L ratio in SAMP2/Iw was higher than that in SAMR1/Iw (p<0.001).

Age-related changes in the D-aspartic acid content of the teeth of the senescence-accelerated mouse.

It is known that D-aspartic acid increases with age in dentine. Here, age-related changes in the D to L-aspartic acid (D/L) ratios of the lower teeth of two different sublines of the senescence-accelerated mouse (SAM), SAMP2/Iw (SAM, prone 2/Iwate) and SAMR1/Iw (SAM, resistant 1/Iwate) were measured by gas chromatography. The D/L ratio of the molars increased with advancing age, whereas that of the incisors did not.

Age-related changes of the cementogenesis in the senescence-accelerated mouse (SAM).

Cementogenesis of the molars with aging was studied using senescence accelerated mouse (SAM) which included SAMP2/Iw and SAMP8@Iw as prone strains, and SAMR1/Iw as a resistant strain. Morphometric analysis was done for the cementum thickness at 2, 6, 12 and 16 months of age on 4 parts of the mice, i.e.

Immunohistochemical detection of ras 21 in oral squamous cell carcinomas.

The expression of the ras p21 in oral squamous cell carcinoma was examined immunohistochemically with the use of a monoclonal antibody NCC-RAS-001 with the avidin-biotin-peroxidase complex method. The expression of ras p21 product was detected in 65.7% (44 of 67 cases) of cancer patients.

Immunohistochemical localization of c-myc oncogene product in oral papilloma.

The expression of c-myc oncogene products in oral papillomas was studied by using an immunohistochemical method. The oncogene products were detected in 17(70.8%) of the 24 oral papillomas under study.