Managing Hereditary Angioedema in a Three-Generation Family: Danazol's Promise in Resource-Limited Settings.

Background Hereditary angioedema (HAE) is a rare disorder in India, and while prevalence data is limited, it is believed that a significant number of individuals may be affected. Due to restricted access to first-line treatments, older therapies like danazol are commonly used despite associated risks in resource-constrained settings. This study aimed to assess the efficacy of danazol as an affordable long-term prophylaxis (LTP) for HAE in a three-generation family.

Protein kinase CK2 sustains de novo fatty acid synthesis by regulating the expression of SCD-1 in human renal cancer cells.

Background: Clear cell renal cell carcinoma (ccRCC) is a type of cancer characterized by a vast intracellular accumulation of lipids that are critical to sustain growth and viability of the cells in the tumour microenvironment. Stearoyl-CoA 9-desaturase 1 (SCD-1) is an essential enzyme for the synthesis of monounsaturated fatty acids and consistently overexpressed in all stages of ccRCC growth.

Methods: Human clear cell renal cell carcinoma lines were treated with small-molecule inhibitors of protein kinase CK2.

Disparities in telehealth utilization between US rural and urban areas during the COVID-19 pandemic.

Purpose: During the COVID-19 pandemic, telehealth services were expanded across the United States to meet the increased demand and safety requirements of care. This observational study aims to understand rural-urban differences in telehealth utilization during the early part of the COVID-19 pandemic.

Methods: Individual-level data from the National Health Interview Survey 2020-2021 (age ≥18) were analyzed for this study.

Impact of synbiotic on growth performance, histo-architectural modulation of lymphoid organ, hematology, blood biochemistry and humoral immune response in naked neck chicken.

Synbiotics, which synergistically enhance the development and activity of beneficial bacteria in the gastrointestinal tract, play a crucial role in the growth and production of chickens. However, their effects on lymphoid organs and immunity in Naked Neck (NN) chickens are not well understood. This experiment aimed to investigate the effects of synbiotics on growth performance, histo-architecture of lymphoid organs, hematology, serum biochemistry, and immunity in NN chickens in Bangladesh.