Publications by authors named "M Saponara"
Even though the Theory of Mind in upper primates has been under investigation for decades, how it may evolve remains an open problem. We propose here an evolutionary game theoretical model where a finite population of individuals may use reasoning strategies to infer a response to the anticipated behavior of others within the context of a sequential dilemma, i.e.
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- The study examines the use of immune checkpoint inhibitors (ICIs) in people living with HIV (PWH) who also have cancer, highlighting their historical exclusion from trials compared to those without HIV.
- A retrospective analysis of 390 PWH treated with anti-PD-1 or anti-PD-L1 therapies shows a diversity of cancers, with a notable response rate and low toxicity profile in this population.
- The findings suggest that the safety and effectiveness of ICIs are comparable between PWH and those without HIV, indicating that PWH can benefit from these cancer treatments without increased adverse effects.
Background: Data on molecular alterations harbored by melanoma brain metastases (MBMs) are limited, and this has hampered the development of more effective therapeutic strategies. We conducted a systematic review and meta-analysis of all the studies reporting DNA sequencing data of MBMs, in order to identify recurrently mutated genes and molecular pathways significantly enriched for genetic alterations.
Methods: We searched PubMed, Embase and Scopus for articles published from the inception of each database to June 30, 2021.
Background: BRAF and MEK inhibitors target therapies (TT) and AntiPD1 immunotherapies (IT) are available first-line treatments for BRAF v600 mutant metastatic melanoma patients. ECOG PS (E), baseline LDH (L), and baseline number of metastatic sites (N) are well-known clinical prognostic markers that identify different prognostic categories of patients. Direct comparison between first-line TT and IT in different prognostic categories could help in first line treatment decision.
View Article and Find Full Text PDFImportance: The association of immune checkpoint inhibitors (ICIs) with patient quality of life has been poorly explored.
Objective: To evaluate patient-reported outcomes (PROs) assessed in randomized clinical trials (RCTs) of immunotherapy-based treatments.
Data Sources: This systematic review and random-effects meta-analysis used RCTs identified in PubMed, MEDLINE, Embase, and Scopus from database inception to June 1, 2021.