A multi-factor knuckle and nail bed verification tool for forensic imagery analysis.

Background: The grooming process involves sexually explicit images or videos sent by the offender to the minor. Although offenders may try to conceal their identity, these sexts often include hand, knuckle, and nail bed imagery.

Objective: We present a novel biometric hand verification tool designed to identify online child sexual exploitation offenders from images or videos based on biometric/forensic features extracted from hand regions.

Unconventional roles of chromatin remodelers and long non-coding RNAs in cell division.

The aim of this review article is to focus on the unconventional roles of epigenetic players (chromatin remodelers and long non-coding RNAs) in cell division, beyond their well-characterized functions in chromatin regulation during cell differentiation and development. In the last two  decades, diverse experimental evidence has shown that subunits of SRCAP and p400/TIP60 chromatin remodeling complexes in humans relocate from interphase nuclei to centrosomes, spindle or midbody, with their depletion yielding an array of aberrant outcomes of mitosis and cytokinesis. Remarkably, this behavior is shared by orthologous subunits of the Drosophila melanogaster DOM/TIP60 complex, despite fruit flies and humans diverged over 700 million years ago.

Evolutionary conserved relocation of chromatin remodeling complexes to the mitotic apparatus.

Background: ATP-dependent chromatin remodeling complexes are multi-protein machines highly conserved across eukaryotic genomes. They control sliding and displacing of the nucleosomes, modulating histone-DNA interactions and making nucleosomal DNA more accessible to specific binding proteins during replication, transcription, and DNA repair, which are processes involved in cell division. The SRCAP and p400/Tip60 chromatin remodeling complexes in humans and the related Drosophila Tip60 complex belong to the evolutionary conserved INO80 family, whose main function is promoting the exchange of canonical histone H2A with the histone variant H2A in different eukaryotic species.