Publications by authors named "M Santagostino"
A novel screening platform for the nickel-catalyzed cyanation of (hetero)aryl halides relying on the use of air-stable Ni(COD)DQ at low loading is reported. Through high-throughput experimentation (HTE), various ligand and solvent combinations are systematically explored, allowing the fast identification of suitable conditions. This standardized workflow serves as an excellent starting point for selecting other competent nickel precatalysts and for further optimization of reluctant substrates.
View Article and Find Full Text PDFNovel cryoballoon technology for atrial fibrillation ablation: Impact of pulmonary vein variant anatomy, cooling characteristics, and 1-year outcome from the CHARISMA registry.
Heart Rhythm
August 2024
Article Synopsis
- This study investigated how different anatomical variations of pulmonary veins (PV) and their cooling characteristics affect recurrence of atrial fibrillation (AF) after cryoballoon (CB) ablation, using data from a large multicenter registry.
- Out of 429 patients with AF, 28 had anatomical variants; the study found no significant difference in AF recurrence rates between those with variants and those with standard anatomy.
- Key factors associated with AF recurrence included shorter thaw and deflation times, while conditions like heart failure and persistent AF were linked to higher recurrence rates during follow-up.
Article Synopsis
- The study investigates the effectiveness of wearable cardioverter defibrillators (WCD) versus early implantable cardioverter defibrillators (ICD) for preventing sudden cardiac death in patients with reduced ejection fraction.
- Out of 41 patients, results showed similar rates of arrhythmias and heart function recovery between the WCD and early ICD groups during the waiting period.
- The use of WCD was found to be more cost-effective, saving about 19.9% per patient in the short term and projected even greater savings over ten years while effectively selecting candidates for ICD implantation.
Closed loop stimulation in left bundle branch area pacing.
Pacing Clin Electrophysiol
September 2024
Introduction: Closed Loop Stimulation (CLS) is a rate-responsive algorithm that adjusts heart rate (HR) based on changes in intracardiac impedance measured from the right ventricle lead. However, the use of CLS in conduction system pacing has not been investigated. In this retrospective study, we aimed to assess whether CLS with left bundle branch area pacing (LBBAP) can generate an appropriate distribution of HR in daily life.
View Article and Find Full Text PDFArticle Synopsis
- Centromeres are defined by the histone variant CENP-A and, unlike most mammals, the horse chromosome 11 lacks satellite DNA.
- The CENP-A binding domain on horse chromosome 11 shifts within a 500 kb area between different individuals, leading to positional alleles that can change but are inherited in a Mendelian manner.
- Research shows that, during development across various tissues, the centromeric domain remains stable, indicating that the centromere sliding does not occur during this time.