Budd-Chiari syndrome with obstruction in the inferior vena cava causes increased venous pressure in the azygous-hemiazygous system and paravertebral venous plexus, which is transmitted to the epidural venous plexus, devoid of the valves. It causes epidural venous plexus engorgement and venous congestion and may present rarely with low back pain or radiating pain. However, patients developing lower limb weakness as a complication of Budd-Chiari syndrome is an infrequent and severe presentation.
View Article and Find Full Text PDFWound healing can often be delayed due to non-favourable physiological conditions. Current treatment strategies have many limitations, and the development of novel therapeutic patches is urgently required. Herein, we have developed a hydrogel-based wound healing patch containing quercetin nanocrystals to enhance quercetin solubility, leading to sustained release and improved bioactivity.
View Article and Find Full Text PDFPediatric intracranial aneurysms (PIAs) are highly uncommon, with an incidence of <5% (0.17 to 4.6%) and <2% of PIA complicates into an aneurysmal hemorrhage.
View Article and Find Full Text PDFImportance: Early evidence from studies outside of oncology has suggested that cannabidiol (CBD) may have anxiolytic effects without neuropsychiatric risks. An understanding of oral CBD in patients with cancer-related anxiety is urgently needed.
Objective: To determine whether a single 400-mg oral dose of a US Food and Drug Administration-approved CBD improves clinical anxiety in an oncologic population.