Publications by authors named "M Sandra Dominguez-Sosa"
Article Synopsis
- - Dupilumab is a new medicine that helps people with severe nasal issues and asthma, and this study looked at how it works for patients who have or haven’t used similar medicines before.
- - The study involved 42 patients, most of whom had asthma, and measured their symptoms and health after 12 months of using dupilumab.
- - Results showed that dupilumab made a big difference in improving patients' symptoms, reducing nasal polyp size, and making overall health better for everyone, no matter their previous treatment history.
Article Synopsis
- - Eosinophil-related diseases have varying symptoms and can range from mild to severe, typically treated with glucocorticoids.
- - Novel biologic therapies targeting the interleukin-5 pathway are gaining approval, offering an alternative to reduce glucocorticoid use and associated side effects.
- - Experts reviewed evidence on glucocorticoid treatment in systemic eosinophilic diseases (like EGPA and HES) and respiratory eosinophilic diseases (like CRSwNP and SA-EP), reaching a consensus on dosing, tapering strategies, and the timing of biologic therapies to minimize adverse effects.
The aim of this study was to evaluate the efficacy of mepolizumab in patients affected by chronic rhinosinusitis with nasal polyps (CRSwNP) in real-life. A single-center retrospective observational study was conducted on severe CRSwNP patients treated with mepolizumab. Nasal endoscopic polyp score (NPS), visual analogue scale (VAS) symptom score, sinonasal outcome test (SNOT-22), asthma control test (ACT) score, fractional exhaled nitric oxide (FeNO), eosinophils blood cells and prednisone intake were assessed at baseline and after 6 months.
View Article and Find Full Text PDFIntroduction And Objectives: Endoscopic sinus surgery is currently the surgical procedure chosen in cases of sinonasal polyposis refractory to medical treatment. The aim of this study was to show our experience in managing such patients operated using endoscopic sinus surgery.
Method: A retrospective study of 246 patients with chronic rhinosinusitis and nasal polyps who were operated by endoscopic surgery.
We present 45 years-old male patient with bilateral luxation of all costochondral joints due to a compression mechanism while he was working beneath a car and the support was lost. He presented with floating sternum and ventilatory compromise among other injuries. Initially he was intubated and the costochondral joints were temporary fixated with dexon suture while making counter balance with 2 kg.
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