Differential Impact of CD43 and CD28 on T-Cell Differentiation Depending on the Order of Engagement with the TCR.

The combination of signals from the T-cell receptor (TCR) and co-stimulatory molecules triggers transcriptional programs that lead to proliferation, cytokine secretion, and effector functions. We compared the impact of engaging the TCR with CD28 and/or CD43 at different time points relative to TCR engagement on T-cell function. TCR and CD43 simultaneous engagement resulted in higher CD69 and PD-1 expression levels than in TCR and CD28-stimulated cells, with a cytokine signature of mostly effector, inflammatory, and regulatory cytokines, while TCR and CD28-activated cells secreted all categories of cytokines, including stimulatory cytokines.

A symmetric version of the Euler equations by using Generalized Bernoulli Method.

The aim of this article is to show a way to extend the usefulness of the Generalized Bernoulli Method (GBM) with the purpose to apply it for the case of variational problems with functionals that depend explicitly of all the variables. Moreover, after expressing the Euler equations in terms of this extension of GBM, we will see that the resulting equations acquire a symmetric form, which is not shared by the known Euler equations. We will see that this symmetry is useful because it allows us to recall these equations with ease.

The novel family of transcendental Leal-functions with applications to science and engineering.

During the phenomena modelling process in the different areas of science and engineering is common to face nonlinear equations without exact solutions; thus, the need of employing numerical methods to obtain such solutions. Therefore, in order to provide new possibilities for the isolation of variables, we propose a novel family of transcendental functions with new algebraic properties including their integration and differentiation rules. Likewise, in order facilitate the numerical evaluation for every new family set of functions, a highly accurate series of approximations is proposed by employing analytical expressions in terms of known transcendental functions and polynomials combinations.

The novel Leal-polynomials for the multi-expansive approximation of nonlinear differential equations.

This work presents the novel Leal-polynomials (LP) for the approximation of nonlinear differential equations of different kind. The main characteristic of LPs is that they satisfy multiple expansion points and its derivatives as a mechanism to replicate behaviour of the nonlinear problem, giving more accuracy within the region of interest. Therefore, the main contribution of this work is that LP satisfies the successive derivatives in some specific points, resulting more accurate polynomials than Taylor expansion does for the same degree of their respective polynomials.

A practical proposal to obtain solutions of certain variational problems avoiding Euler formalism.

The aim of this article is to show the way to get both, exact and analytical approximate solutions for certain variational problems with moving boundaries but without resorting to Euler formalism at all, for which we propose two methods: the Moving Boundary Conditions Without Employing Transversality Conditions (MWTC) and the Moving Boundary Condition Employing Transversality Conditions (METC). It is worthwhile to mention that the first of them avoids the concept of transversality condition, which is basic for this kind of problems, from the point of view of the known Euler formalism. While it is true that the second method will utilize the above mentioned conditions, it will do through a systematic elementary procedure, easy to apply and recall; in addition, it will be seen that the Generalized Bernoulli Method (GBM) will turn out to be a fundamental tool in order to achieve these objectives.