Publications by authors named "M Sampedro"
Background And Objectives: Primary objectives: to compare the rates of sustained clinical remission at 12 months in patients treated with antitumour necrosis factor (anti-TNF) and immunomodulators who withdraw anti-TNF treatment versus those who maintain it.
Secondary Objectives: to evaluate the effect of anti-TNF withdrawal on relapse-free time, endoscopic and radiological activity, safety, quality of life and work productivity; and to identify predictive factors for relapse.
Design: Prospective, quadruple-blind, multicentre, randomised, controlled trial.
Objective: To evaluate the therapeutic dose and safety of bemiparin in neonatal thrombosis treatment.
Study Design: A retrospective review was conducted on infants treated with bemiparin between 2018 and 2023 at a tertiary hospital.
Results: 72 neonates with a mean gestational age of 37 weeks were included.
Article Synopsis
- Angelman syndrome (AS) is a rare genetic disorder impacting neurodevelopment, with an estimated prevalence of 1 in 20,000, but lacks comprehensive data on life expectancy and death rates due to a lack of diagnostic codes until 2018.
- A social media initiative by AS caregivers gathered data on 220 deaths, revealing respiratory illness as the leading cause, followed by accidents and seizures, with sudden unexpected death in sleep (SUDS) also being a notable concern.
- The study found that 91% of individuals with AS have epilepsy, suggesting that some SUDS cases could relate to sudden unexpected deaths in epilepsy (SUDEP), and highlights the need for more research despite limitations
Objective: The aim of this study is to compare the response to first-line medical treatment in treatment-naive acromegaly patients with pure growth hormone (GH)-secreting pituitary adenoma (GH-PA) and those with GH and prolactin cosecreting PA (GH&PRL-PA).
Design: This is a retrospective multicentric study of acromegaly patients followed from 2003 to 2023 in 33 tertiary Spanish hospitals with at least 6 months of first-line medical treatment.
Methods: Baseline characteristics, first-line medical treatment strategies, and outcomes were analyzed.
Article Synopsis
- A study evaluated the differences in clinical presentation and surgical outcomes between two types of pituitary adenomas: growth hormone secreting (GH-PAs) and those that cosecrete growth hormone and prolactin (GH&PRL-PAs).
- GH&PRL-PAs were found to occur more frequently as macroadenomas, had a lower average age at diagnosis, and were more likely to show signs of invasiveness and hypopituitarism compared to GH-PAs.
- Despite these differences in presentation, both groups had similar rates of surgical success in terms of biochemical cure, although GH&PRL-PA patients experienced a higher incidence of permanent arginine-vasopressin deficiency