Publications by authors named "M Samimi"
The cell adhesion protein CD56 has been identified as a potential therapeutic target in several solid tumors and hematological malignancies. Recently, we developed a CD56-directed antibody-drug conjugate (ADC), called Adcitmer and demonstrated its antitumor properties in preclinical models of the rare and aggressive skin cancer Merkel cell carcinoma (MCC).The present study aims to further optimize Adcitmer to overcome the therapeutic limitations observed with previously evaluated CD56-targeting ADCs, which were partially related to toxic effects on leukocytes.
View Article and Find Full Text PDFMerkel cell carcinoma (MCC) is a rare skin cancer that mainly affects the elderly, and whose incidence is increasing. Although the exact origin of this cancer remains uncertain, research in recent years has revealed that MCC develops through two oncogenesis pathways: virally induced by the Merkel polyomavirus (80% of cases) and induced by mutations linked to ultraviolet rays (20% of cases). MCC is an aggressive cancer, with a high mortality rate and limited therapeutic options in advanced stage.
View Article and Find Full Text PDFRecurrent mutations in the CTNNB1 or APC genes leading to the activation of the Wnt/betacatenin pathway are observed in adnexal tumors with matrical differentiation. While most pilomatricomas arise sporadically and harbor CTNNB1 mutations, cutaneous hybrid cysts combining epidermal and matrical differentiations have been mostly reported in a context of the familial adenomatosis polyposis/Gardner's syndrome related to germinal mutations of APC. The objective of this study is to understand the pathogenesis of hybrid cysts combining epidermal and matrical differentiations.
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- Polycystic ovary syndrome (PCOS) is a common reproductive health issue in women linked to obesity, and this study explores the relationship between diet (measured by the Dietary Obesity Prevention Score or DOS) and PCOS for the first time.
- The study involved 100 women with PCOS and 100 without, measuring their dietary habits, blood markers, and body measurements to assess the impact of DOS on health outcomes.
- Results showed that higher adherence to DOS was associated with lower inflammation levels (CRP) and marginally higher fasting blood sugar, but no significant direct link between DOS and PCOS risk was found.
Article Synopsis
- Spontaneous coronary artery dissection (SCAD) is a rare form of acute coronary syndrome that mainly affects young and middle-aged women, but can also occur in young men, especially those with fibromuscular dysplasia.
- A case is presented involving a young man with fibromuscular dysplasia who experienced recurrent SCAD in the right coronary artery despite receiving conservative treatment.
- The study emphasizes the need for more research on the underlying mechanisms of SCAD in men and the development of effective medical therapies for preventing recurrent episodes.