An immunoinformatics and extensive molecular dynamics study to develop a polyvalent multi-epitope vaccine against cryptococcosis.

Cryptococcosis is a lethal mycosis instigated by the pathogenic species Cryptococcus neoformans and Cryptococcus gattii, primarily affects the lungs, manifesting as pneumonia, and the brain, where it presents as meningitis. Mortality rate could reach 100% if infections remain untreated in cryptococcal meningitis. Treatment options for cryptococcosis are limited and and there are no licensed vaccines clinically available to treat or prevent cryptococcosis.

ChatGPT-4 Turbo and Meta's LLaMA 3.1: A Relative Analysis of Answering Radiology Text-Based Questions.

Aims And Objectives: This study aimed to compare the accuracy of two AI models - OpenAI's GPT-4 Turbo (San Francisco, CA) and Meta's LLaMA 3.1 (Menlo Park, CA) - when answering a standardized set of pediatric radiology questions. The primary objective was to evaluate the overall accuracy of each model, while the secondary objective was to assess their performance within subsections.

Evaluation of ChatGPT 4.0 in Thoracic Imaging and Diagnostics.

Recent advancements in natural language processing (NLP) have profoundly transformed the medical industry, enhancing large cohort data analysis, improving diagnostic capabilities, and streamlining clinical workflows. Among the leading tools in this domain is ChatGPT 4.0 (OpenAI, San Francisco, California, US), a commercial NLP model widely used across various applications.

Protective Effects of Donkey Milk on Ethanol-Induced Gastric Ulcer in Rat.

Gastric ulcer (GU) is the most common health concern that occurs due to an imbalance between gastric protective mucosal and aggressive factors. Ethanol-induced GU in animal models resembles the pathophysiology of human ulcers. Natural products with fewer side effects are highly requested to attenuate their GU effects.

Radiographic association of chronological age based on the root pulp and periodontal ligament visibility in lower second molar teeth in a subset of the Pakistani population.

Objectives: To find radiographic association of the root pulp visibility and periodontal ligament visibility stages of lower second molar teeth with chronological age.

Methods: The prospective, analytical, cross-sectional study was conducted after approval from the ethics review committee of Ziauddin University, Karachi, and comprised digital orthopantomograms from 2020 to 2022. The orthopantomograms related to lower second molar teeth from the left side of the mandible of individuals of either gender aged 18-40 years.