Publications by authors named "M Salvucci"
Colorectal cancer (CRC) is one of the most frequently occurring cancers, but prognostic biomarkers identifying patients at risk of recurrence are still lacking. In this study, we aimed to investigate in more detail the spatial relationship between intratumoural T cells, cancer cells, and cancer cell hallmarks as prognostic biomarkers in stage III colorectal cancer patients. We conducted multiplexed imaging of 56 protein markers at single-cell resolution on resected fixed tissue from stage III CRC patients who received adjuvant 5-fluorouracil (5FU)-based chemotherapy.
View Article and Find Full Text PDFMucinous colorectal cancer (CRC) is a common histological subtype of colorectal adenocarcinoma, associated with a poor response to chemoradiotherapy. The commensal facultative anaerobes fusobacteria, have been associated with poor prognosis specifically in mesenchymal CRC. Interestingly, fusobacterial infection is especially prevalent in mucinous CRC.
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- The study critiques existing colorectal cancer subtyping methods, noting they fail to account for differences between colon and rectal tissues, especially in the context of chemotherapy.
- Researchers analyzed mRNA expression profiles from 2,121 cancer samples, discovering that neoadjuvant chemoradiotherapy alters subtype classifications in rectal cancer, leading to the identification of three specific subtypes (RSSs).
- These three subtypes (RSS1, RSS2, and RSS3) showed distinct disease-free survival rates and underlying biological characteristics, indicating that this new subtyping method outperforms traditional methods in assessing prognosis and potential treatment pathways for rectal cancer.
Colorectal cancer (CRC) is one of the most frequently occurring cancers, but prognostic biomarkers identifying patients at risk of recurrence are still lacking. In this study, we aimed to investigate in more detail the spatial relationship between intratumoural T cells, cancer cells, and cancer cell hallmarks, as prognostic biomarkers in stage III colorectal cancer patients. We conducted multiplexed imaging of 56 protein markers at single cell resolution on resected fixed tissue from stage III CRC patients who received adjuvant 5-fluorouracil-based chemotherapy.
View Article and Find Full Text PDFChemotherapy using temozolomide is the standard treatment for patients with glioblastoma. Despite treatment, prognosis is still poor largely due to the emergence of temozolomide resistance. This resistance is closely linked to the widely recognized inter- and intra-tumoral heterogeneity in glioblastoma, although the underlying mechanisms are not yet fully understood.
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